(4R,6S)-6-<(tert-Butyldimethylsilyl)oxy>-4-<(tert-butyldiphenylsilyl)oxy>-2-cyclohepten-1-one

Base Information

Chemical Name:(4R,6S)-6-<(tert-Butyldimethylsilyl)oxy>-4-<(tert-butyldiphenylsilyl)oxy>-2-cyclohepten-1-one
CAS No.:151936-86-6
Molecular Formula:C₂₉H₄₂O₃Si₂
Molecular Weight:494.822
Hs Code.:

Synonyms:(4R,6S)-6-<(tert-Butyldimethylsilyl)oxy>-4-<(tert-butyldiphenylsilyl)oxy>-2-cyclohepten-1-one

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Chemical Property of (4R,6S)-6-<(tert-Butyldimethylsilyl)oxy>-4-<(tert-butyldiphenylsilyl)oxy>-2-cyclohepten-1-one

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Technology Process of (4R,6S)-6-<(tert-Butyldimethylsilyl)oxy>-4-<(tert-butyldiphenylsilyl)oxy>-2-cyclohepten-1-one

There total 7 articles about (4R,6S)-6-<(tert-Butyldimethylsilyl)oxy>-4-<(tert-butyldiphenylsilyl)oxy>-2-cyclohepten-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (1S,4R,6R)-6-(tert-Butyl-dimethyl-silanyloxy)-4-(tert-butyl-diphenyl-silanyloxy)-cyclohept-2-enol

: 151936-86-6
(4R,6S)-6-<(tert-Butyldimethylsilyl)oxy>-4-<(tert-butyldiphenylsilyl)oxy>-2-cyclohepten-1-one

Guidance literature:: With 4 A molecular sieve; In dichloromethane; for 6h; Yield given;
DOI:10.1021/jo00077a049

Reference yield:

: 1121-63-7
cyclohepta-3,5-dien-1-ol

: 151936-86-6
(4R,6S)-6-<(tert-Butyldimethylsilyl)oxy>-4-<(tert-butyldiphenylsilyl)oxy>-2-cyclohepten-1-one

Guidance literature:: Multi-step reaction with 7 steps

1: 88 percent / imidazole / dimethylformamide

2: 76 percent / 1O₂ / CH₂Cl₂; methanol

3: 98 percent / Zn, HOAc / CH₂Cl₂ / 0 °C

4: 98 percent / 50 °C / Amano P-30 lipase

5: 97 percent / imidazole / dimethylformamide / 8 h / Ambient temperature

6: KOH / methanol / 1 h

7: pyridinium dichromate 4 Angstroem molecular sieves / CH₂Cl₂ / 6 h

With 1H-imidazole; potassium hydroxide; 4 A molecular sieve; oxygen; acetic acid; zinc; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo00077a049

Reference yield:

: 134734-52-4
(1R,4S,6S)-4-acetoxy-6-[(tert-butyldimethylsilyl)oxy]-2-cyclohepten-1-ol

: 151936-86-6
(4R,6S)-6-<(tert-Butyldimethylsilyl)oxy>-4-<(tert-butyldiphenylsilyl)oxy>-2-cyclohepten-1-one

Guidance literature:: Multi-step reaction with 3 steps

1: 97 percent / imidazole / dimethylformamide / 8 h / Ambient temperature

2: KOH / methanol / 1 h

3: pyridinium dichromate 4 Angstroem molecular sieves / CH₂Cl₂ / 6 h

With 1H-imidazole; potassium hydroxide; 4 A molecular sieve; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo00077a049