5-{1-[(2,5-difluorophenyl)acetyl]-2,3-dihydro-1H-indol-5-yl} thieno[2,3-d]pyrimidin-4-amine

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Chemical Name:5-{1-[(2,5-difluorophenyl)acetyl]-2,3-dihydro-1H-indol-5-yl} thieno[2,3-d]pyrimidin-4-amine
CAS No.:1337531-23-3
Molecular Formula:C₂₂H₁₆F₂N₄OS
Molecular Weight:422.458
Hs Code.:

Synonyms:5-{1-[(2,5-difluorophenyl)acetyl]-2,3-dihydro-1H-indol-5-yl} thieno[2,3-d]pyrimidin-4-amine

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Chemical Property of 5-{1-[(2,5-difluorophenyl)acetyl]-2,3-dihydro-1H-indol-5-yl} thieno[2,3-d]pyrimidin-4-amine

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Technology Process of 5-{1-[(2,5-difluorophenyl)acetyl]-2,3-dihydro-1H-indol-5-yl} thieno[2,3-d]pyrimidin-4-amine

There total 7 articles about 5-{1-[(2,5-difluorophenyl)acetyl]-2,3-dihydro-1H-indol-5-yl} thieno[2,3-d]pyrimidin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1337532-92-9
5-bromo-thieno[2,3-d]pyrimidin-4-ylamine

: 1337532-54-3
5-bromo-1-[(2,5-difluorophenyl)acetyl]-2,3-dihydro-1H-indole

: 1337531-23-3
5-{1-[(2,5-difluorophenyl)acetyl]-2,3-dihydro-1H-indol-5-yl} thieno[2,3-d]pyrimidin-4-amine

Guidance literature:: 5-bromo-1-[(2,5-difluorophenyl)acetyl]-2,3-dihydro-1H-indole; With potassium acetate; bis(pinacol)diborane; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; at 100 ℃; for 3h; Inert atmosphere; Sealed vessel;

5-bromo-thieno[2,3-d]pyrimidin-4-ylamine; With sodium hydrogencarbonate; In 1,4-dioxane; water; at 20 - 100 ℃; Inert atmosphere;

Reference yield:

: 814918-95-1
5-bromo-4-chlorothieno[2,3-d]pyrimidine

: 1337531-23-3
5-{1-[(2,5-difluorophenyl)acetyl]-2,3-dihydro-1H-indol-5-yl} thieno[2,3-d]pyrimidin-4-amine

Guidance literature:: Multi-step reaction with 2 steps

1.1: ammonium hydroxide / water / 90 °C / Sealed vessel

2.1: bis(pinacol)diborane; potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 3 h / 100 °C / Inert atmosphere; Sealed vessel

2.2: 20 - 100 °C / Inert atmosphere

With ammonium hydroxide; potassium acetate; bis(pinacol)diborane; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; water;

Reference yield:

: 1337532-92-9
5-bromo-thieno[2,3-d]pyrimidin-4-ylamine

: 1337533-26-2
1-[(2,5-difluorophenyl)acetyl]-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydro-1H-indole

: 1337531-23-3
5-{1-[(2,5-difluorophenyl)acetyl]-2,3-dihydro-1H-indol-5-yl} thieno[2,3-d]pyrimidin-4-amine

Guidance literature:: With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium hydrogencarbonate; In 1,4-dioxane; water; at 20 - 100 ℃; Sealed tube; Inert atmosphere;
DOI:10.1021/jm300713s