1-ethyl-3-{5-mercapto-4-(4-nitrobenzylideneamino)-4H-1,2,4-triazol-3-yl}-7-methyl-1,8-naphthyridin-4(1H)-one

Base Information

• Chemical Name: 1-ethyl-3-{5-mercapto-4-(4-nitrobenzylideneamino)-4H-1,2,4-triazol-3-yl}-7-methyl-1,8-naphthyridin-4(1H)-one
• CAS No.: 1334935-96-4
• Molecular Formula: C₂₀H₁₇N₇O₃S
• Molecular Weight: 435.466
• Mol file: 1334935-96-4.mol

Synonyms:1-ethyl-3-{5-mercapto-4-(4-nitrobenzylideneamino)-4H-1,2,4-triazol-3-yl}-7-methyl-1,8-naphthyridin-4(1H)-one

Chemical Property of 1-ethyl-3-{5-mercapto-4-(4-nitrobenzylideneamino)-4H-1,2,4-triazol-3-yl}-7-methyl-1,8-naphthyridin-4(1H)-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-ethyl-3-{5-mercapto-4-(4-nitrobenzylideneamino)-4H-1,2,4-triazol-3-yl}-7-methyl-1,8-naphthyridin-4(1H)-one

There total 4 articles about 1-ethyl-3-{5-mercapto-4-(4-nitrobenzylideneamino)-4H-1,2,4-triazol-3-yl}-7-methyl-1,8-naphthyridin-4(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

3-(4-amino-5-mercapto-4H-1,2,4-triazol-3-yl)-1-ethyl-7-methyl-1,8-naphthyridin-4(1H)-one (1216936-53-6) + 4-nitrobenzaldehdye (555-16-8) → 1-ethyl-3-{5-mercapto-4-(4-nitrobenzylideneamino)-4H-1,2,4-triazol-3-yl}-7-methyl-1,8-naphthyridin-4(1H)-one (1334935-96-4)

Guidance literature:

With sulfuric acid; In 1,4-dioxane; for 3h; Reflux;

DOI:10.1016/j.ejmech.2011.06.009

Reference yield:

methyl 1-ethyl-1,4-dihydro-7-methyl-4-oxo-1, 8-naphthyridine-3-carboxylate (63475-29-6) → 1-ethyl-3-{5-mercapto-4-(4-nitrobenzylideneamino)-4H-1,2,4-triazol-3-yl}-7-methyl-1,8-naphthyridin-4(1H)-one (1334935-96-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: hydrazine hydrate / tetrahydrofuran / 3 h / Reflux

2.1: potassium hydroxide / ethanol / 20 °C

2.2: 5 h / Reflux

3.1: sulfuric acid / 1,4-dioxane / 3 h / Reflux

With sulfuric acid; hydrazine hydrate; potassium hydroxide; In tetrahydrofuran; 1,4-dioxane; ethanol;

DOI:10.1016/j.ejmech.2011.06.009

Reference yield:

nalidixic Acid (389-08-2) → 1-ethyl-3-{5-mercapto-4-(4-nitrobenzylideneamino)-4H-1,2,4-triazol-3-yl}-7-methyl-1,8-naphthyridin-4(1H)-one (1334935-96-4)

Guidance literature:

Multi-step reaction with 4 steps

1.1: potassium carbonate / tetrahydrofuran / 1 h

1.2: 70 °C

2.1: hydrazine hydrate / tetrahydrofuran / 3 h / Reflux

3.1: potassium hydroxide / ethanol / 20 °C

3.2: 5 h / Reflux

4.1: sulfuric acid / 1,4-dioxane / 3 h / Reflux

With sulfuric acid; potassium carbonate; hydrazine hydrate; potassium hydroxide; In tetrahydrofuran; 1,4-dioxane; ethanol;

DOI:10.1016/j.ejmech.2011.06.009

upstream raw materials:

3-(4-amino-5-mercapto-4H-1,2,4-triazol-3-yl)-1-ethyl-7-methyl-1,8-naphthyridin-4(1H)-one

4-nitrobenzaldehdye

methyl 1-ethyl-1,4-dihydro-7-methyl-4-oxo-1, 8-naphthyridine-3-carboxylate

nalidixic Acid