3-(4-((3,4-difluorobenzamido)methyl)-1H-1,2,3-triazol-1-yl)-2-(R,S)-hydroxypropyl 2,3,4,6-tetra-O-acetyl-α-D-galactopyranoside

Base Information

Chemical Name:3-(4-((3,4-difluorobenzamido)methyl)-1H-1,2,3-triazol-1-yl)-2-(R,S)-hydroxypropyl 2,3,4,6-tetra-O-acetyl-α-D-galactopyranoside
CAS No.:1310419-29-4
Molecular Formula:C₂₇H₃₂F₂N₄O₁₂
Molecular Weight:642.567
Hs Code.:

Synonyms:3-(4-((3,4-difluorobenzamido)methyl)-1H-1,2,3-triazol-1-yl)-2-(R,S)-hydroxypropyl 2,3,4,6-tetra-O-acetyl-α-D-galactopyranoside

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Chemical Property of 3-(4-((3,4-difluorobenzamido)methyl)-1H-1,2,3-triazol-1-yl)-2-(R,S)-hydroxypropyl 2,3,4,6-tetra-O-acetyl-α-D-galactopyranoside

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Technology Process of 3-(4-((3,4-difluorobenzamido)methyl)-1H-1,2,3-triazol-1-yl)-2-(R,S)-hydroxypropyl 2,3,4,6-tetra-O-acetyl-α-D-galactopyranoside

There total 3 articles about 3-(4-((3,4-difluorobenzamido)methyl)-1H-1,2,3-triazol-1-yl)-2-(R,S)-hydroxypropyl 2,3,4,6-tetra-O-acetyl-α-D-galactopyranoside which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1250231-35-6
3,4-difluoro-N-(prop-2-ynyl)benzamide

: 1310419-18-1
(R,S)-3-azido-2-hydroxypropyl 2,3,4,6-tetra-O-acetyl-α-D-galactopyranoside

: 1310419-29-4
3-(4-((3,4-difluorobenzamido)methyl)-1H-1,2,3-triazol-1-yl)-2-(R,S)-hydroxypropyl 2,3,4,6-tetra-O-acetyl-α-D-galactopyranoside

Guidance literature:: With copper(II) sulfate; sodium L-ascorbate; In methanol; water; at 20 ℃; for 24h; Inert atmosphere;
DOI:10.1039/c0ob01089h

Reference yield:

: 76903-88-3
3,4-difluorobenzoyl chloride

: 1310419-29-4
3-(4-((3,4-difluorobenzamido)methyl)-1H-1,2,3-triazol-1-yl)-2-(R,S)-hydroxypropyl 2,3,4,6-tetra-O-acetyl-α-D-galactopyranoside

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / dichloromethane / 0 - 20 °C / Inert atmosphere

2: copper(II) sulfate; sodium L-ascorbate / methanol; water / 24 h / 20 °C / Inert atmosphere

With pyridine; copper(II) sulfate; sodium L-ascorbate; In methanol; dichloromethane; water;
DOI:10.1039/c0ob01089h

Reference yield:

: 78780-77-5
(R,S)-2,3-epoxypropyl 2,3,4,6-tetra-O-acetyl-α-D-galactopyranoside

: 1310419-29-4
3-(4-((3,4-difluorobenzamido)methyl)-1H-1,2,3-triazol-1-yl)-2-(R,S)-hydroxypropyl 2,3,4,6-tetra-O-acetyl-α-D-galactopyranoside

Guidance literature:: Multi-step reaction with 2 steps

1: sodium azide; ammonium chloride / N,N-dimethyl-formamide / 7.5 h / 55 °C / Inert atmosphere

2: copper(II) sulfate; sodium L-ascorbate / methanol; water / 24 h / 20 °C / Inert atmosphere

With sodium azide; ammonium chloride; copper(II) sulfate; sodium L-ascorbate; In methanol; water; N,N-dimethyl-formamide;
DOI:10.1039/c0ob01089h