Technology Process of ethyl (E)-3-(6-methyl-2,3,4,5-tetramethoxyphenyl)-2-propenoate
There total 3 articles about ethyl (E)-3-(6-methyl-2,3,4,5-tetramethoxyphenyl)-2-propenoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
diethoxyphosphoryl-acetic acid ethyl ester;
With
sodium hydride;
In
tetrahydrofuran; mineral oil;
at 0 - 20 ℃;
for 0.166667h;
Inert atmosphere;
2,3,4,5-tetramethoxy-6-methyl benzaldehyde;
In
tetrahydrofuran; mineral oil;
at 20 ℃;
for 0.0833333h;
Inert atmosphere;
DOI:10.1021/ja308529n
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: palladium on activated charcoal; hydrogen / methanol / 20 °C
1.2: Reflux; Inert atmosphere
2.1: titanium tetrachloride / dichloromethane / 6 h / 0 - 20 °C / Inert atmosphere
3.1: sodium hydride / tetrahydrofuran; mineral oil / 0.17 h / 0 - 20 °C / Inert atmosphere
3.2: 0.08 h / 20 °C / Inert atmosphere
With
palladium on activated charcoal; hydrogen; titanium tetrachloride; sodium hydride;
In
tetrahydrofuran; methanol; dichloromethane; mineral oil;
DOI:10.1021/ja308529n
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: titanium tetrachloride / dichloromethane / 6 h / 0 - 20 °C / Inert atmosphere
2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.17 h / 0 - 20 °C / Inert atmosphere
2.2: 0.08 h / 20 °C / Inert atmosphere
With
titanium tetrachloride; sodium hydride;
In
tetrahydrofuran; dichloromethane; mineral oil;
DOI:10.1021/ja308529n
