2-(5-(benzyloxycarbonylamino)-4-(tert-butoxycarbonyl)thiophene-2-yl)acetic acid

Base Information

• Chemical Name: 2-(5-(benzyloxycarbonylamino)-4-(tert-butoxycarbonyl)thiophene-2-yl)acetic acid
• CAS No.: 1134809-35-0
• Molecular Formula: C₁₉H₂₁NO₆S
• Molecular Weight: 391.445
• Mol file: 1134809-35-0.mol

Synonyms:2-(5-(benzyloxycarbonylamino)-4-(tert-butoxycarbonyl)thiophene-2-yl)acetic acid

Chemical Property of 2-(5-(benzyloxycarbonylamino)-4-(tert-butoxycarbonyl)thiophene-2-yl)acetic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(5-(benzyloxycarbonylamino)-4-(tert-butoxycarbonyl)thiophene-2-yl)acetic acid

There total 1 articles about 2-(5-(benzyloxycarbonylamino)-4-(tert-butoxycarbonyl)thiophene-2-yl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

tert-butyl 5-(benzyloxycarbonylamino)-2-(2-methoxy-2-oxoethyl)thiophene-4-carboxylate (1134809-29-2) → 2-(5-(benzyloxycarbonylamino)-4-(tert-butoxycarbonyl)thiophene-2-yl)acetic acid (1134809-35-0)

Guidance literature:

With lithium hydroxide; water; In tetrahydrofuran; at 20 ℃; for 2h;

DOI:10.1055/s-0028-1087243

Reference yield: 81.0%

tert-butyl 2-amino-5-(2-methoxy-2-oxoethyl)thiophene-3-carboxylate (1134809-19-0) + 2-(5-(benzyloxycarbonylamino)-4-(tert-butoxycarbonyl)thiophene-2-yl)acetic acid (1134809-35-0) → C31H36N2O9S2 (1260217-59-1)

Guidance literature:

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 24h; Inert atmosphere;

DOI:10.1002/ejoc.201001066

Reference yield: 80.0%

2-(5-(benzyloxycarbonylamino)-4-(tert-butoxycarbonyl)thiophene-2-yl)acetic acid (1134809-35-0) + methyl (2S)-2-amino-3-phenylpropanoate hydrochloride (7524-50-7) → C29H32N2O7S (1134809-10-1)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; In dichloromethane; at 20 ℃; for 24h;

DOI:10.1055/s-0028-1087243

upstream raw materials:

tert-butyl 5-(benzyloxycarbonylamino)-2-(2-methoxy-2-oxoethyl)thiophene-4-carboxylate

Downstream raw materials:

C₂₉H₃₂N₂O₇S

C₃₁H₃₆N₂O₉S₂