N-Hydroxy-4-methylbenzamide

Base Information

• Chemical Name: N-Hydroxy-4-methylbenzamide
• CAS No.: 2318-82-3
• Molecular Formula: C8H9 N O2
• Molecular Weight: 151.165
• Hs Code.: 2924299090
• Mol file: 2318-82-3.mol

Synonyms:p-Toluhydroxamicacid (6CI,7CI,8CI); 4-Methylbenzohydroxamic acid; 4-Methylphenylhydroxamicacid; N-Hydroxy-4-methylbenzamide; p-Methylbenzohydroxamic acid;p-Toluohydroxamic acid; p-Toluylhydroxamic acid

Chemical Property of N-Hydroxy-4-methylbenzamide

Chemical Property:

• Melting Point: 147 °C
• PKA: 9.04±0.10(Predicted)
• PSA: 49.33000
• Density: 1.189±0.06 g/cm3(Predicted)
• LogP: 1.50490

Purity/Quality:

99% ^*data from raw suppliers

N-HYDROXY-4-METHYLBENZAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-Hydroxy-4-methylbenzamide

There total 10 articles about N-Hydroxy-4-methylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-methyl-benzoyl chloride (874-60-2) → N-hydroxy-4-methylbenzamide (2318-82-3)

Guidance literature:

With hydroxylamine hydrochloride; sodium hydrogencarbonate; In water; ethyl acetate; at 20 ℃; for 0.0833333h;

DOI:10.1007/s00775-020-01755-6

Reference yield: 99.0%

4-methyl-benzaldehyde (104-87-0) → N-hydroxy-4-methylbenzamide (2318-82-3)

Guidance literature:

With polymer-bound N-hydroxybenzenesulfonamide; sodium methylate; In tetrahydrofuran; methanol; at 20 ℃; for 7h;

DOI:10.1021/jo061018g

Reference yield: 90.0%

p-Toluic acid (99-94-5) → N-hydroxy-4-methylbenzamide (2318-82-3)

Guidance literature:

With N-Bromosuccinimide; hydroxylamine hydrochloride; triphenylphosphine; In triethylamine; acetonitrile; at 20 ℃; for 2h;

DOI:10.1002/jccs.200000140

upstream raw materials:

4-methyl-benzoic acid methyl ester

4-methylbenzoic acid ethyl ester

4-methyl-benzoyl chloride

p-Toluic acid

Downstream raw materials:

N-acetoacetyloxy-4-methylbenzamide

3-(4-methyl-benzoyl)-3,4-dihydro-benzo[d][1,2]oxazin-1-one

6-chloro-3-(4-methyl-benzoyl)-3,4-dihydro-benzo[d][1,2]oxazin-1-one

N-acetoxy-4-methyl-benzamide