allyl 6-methyl-4-(3-nitrophenyl)-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Base Information

Chemical Name:allyl 6-methyl-4-(3-nitrophenyl)-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
CAS No.:879863-15-7
Molecular Formula:C₁₅H₁₅N₃O₄S
Molecular Weight:333.368
Hs Code.:

Synonyms:allyl 6-methyl-4-(3-nitrophenyl)-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of allyl 6-methyl-4-(3-nitrophenyl)-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

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Technology Process of allyl 6-methyl-4-(3-nitrophenyl)-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

There total 1 articles about allyl 6-methyl-4-(3-nitrophenyl)-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 1118-84-9
allyl acetoacetate

: 99-61-6
3-nitro-benzaldehyde

: 17356-08-0
thiourea

: 879863-15-7
allyl 6-methyl-4-(3-nitrophenyl)-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Guidance literature:: With ytterbium(III) triflate; In acetonitrile; at 120 ℃; for 0.333333h; microwave irradiation;
DOI:10.1016/j.tet.2005.12.061

Reference yield: 57.0%

: 879863-15-7
allyl 6-methyl-4-(3-nitrophenyl)-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

: 1,2,3,4-tetrahydro-6-methyl-4-(3-nitrophenyl)-2-thioxopyrimidine-5-carboxylic acid

Guidance literature:: With Diethyl amine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; at 25 ℃;
DOI:10.1016/j.tet.2005.12.061

Reference yield:

: 879863-15-7
allyl 6-methyl-4-(3-nitrophenyl)-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

: N-propyl-1,2,3,4-tetrahydro-6-methyl-2-thioxo-4-(3-nitrophenyl)-pyrimidine-5-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: 57 percent / diethyl amine / Pd(PPh₃)4 / tetrahydrofuran / 25 °C

2: 57 percent / polystyrene-supported carbodiimide; 1-hydroxybenzotriazole / N,N-dimethyl-acetamide / 0.25 h / 100 - 120 °C / microwave irradiation

With Diethyl amine; polystyrene-supported carbodiimide; benzotriazol-1-ol; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; N,N-dimethyl acetamide;
DOI:10.1016/j.tet.2005.12.061