N-[(4-chlorophenyl)sulfonyl]-3-(4-chlorophenyl)-4-(4-fluorophenyl)-4,5-dihydro-1H-pyrazole-1-carboxamide

Base Information

Chemical Name:N-[(4-chlorophenyl)sulfonyl]-3-(4-chlorophenyl)-4-(4-fluorophenyl)-4,5-dihydro-1H-pyrazole-1-carboxamide
CAS No.:656827-56-4
Molecular Formula:C₂₂H₁₆Cl₂FN₃O₃S
Molecular Weight:492.358
Hs Code.:

Synonyms:N-[(4-chlorophenyl)sulfonyl]-3-(4-chlorophenyl)-4-(4-fluorophenyl)-4,5-dihydro-1H-pyrazole-1-carboxamide

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Chemical Property of N-[(4-chlorophenyl)sulfonyl]-3-(4-chlorophenyl)-4-(4-fluorophenyl)-4,5-dihydro-1H-pyrazole-1-carboxamide

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Technology Process of N-[(4-chlorophenyl)sulfonyl]-3-(4-chlorophenyl)-4-(4-fluorophenyl)-4,5-dihydro-1H-pyrazole-1-carboxamide

There total 4 articles about N-[(4-chlorophenyl)sulfonyl]-3-(4-chlorophenyl)-4-(4-fluorophenyl)-4,5-dihydro-1H-pyrazole-1-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 34543-04-9
N-[(4-chlorophenyl)sulfonyl]carbamic acid methyl ester

: 656827-53-1
3-(4-chlorophenyl)-4-(4-fluorophenyl)-4,5-dihydro-1H-pyrazole

: 656827-56-4
N-[(4-chlorophenyl)sulfonyl]-3-(4-chlorophenyl)-4-(4-fluorophenyl)-4,5-dihydro-1H-pyrazole-1-carboxamide

Guidance literature:: In toluene; for 4h; Heating;
DOI:10.1021/jm031019q

Reference yield:

: 98-64-6
4-Chlorobenzenesulfonamide

: 656827-56-4
N-[(4-chlorophenyl)sulfonyl]-3-(4-chlorophenyl)-4-(4-fluorophenyl)-4,5-dihydro-1H-pyrazole-1-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: 75 percent / Et₃N / acetonitrile / 6 h / 20 °C

2: 78 percent / toluene / 4 h / Heating

With triethylamine; In toluene; acetonitrile;
DOI:10.1021/jm031019q

Reference yield:

: 126866-15-7
1-(4-chlorophenyl)-2-(4-fluorophenyl)ethanone

: 656827-56-4
N-[(4-chlorophenyl)sulfonyl]-3-(4-chlorophenyl)-4-(4-fluorophenyl)-4,5-dihydro-1H-pyrazole-1-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / piperidine; AcOH / methanol; H₂O / 4 h / Heating

2: 59 percent / hydrazine hydrate / ethanol / 3 h / Heating

3: 78 percent / toluene / 4 h / Heating

With piperidine; hydrazine hydrate; acetic acid; In methanol; ethanol; water; toluene;
DOI:10.1021/jm031019q