ethyl 4-[1-(2-fluoro-4-bromobenzyl)-5-chlorobenzimidazol-2-yl]-3,3-dimethylbutanoate

Base Information

Chemical Name:ethyl 4-[1-(2-fluoro-4-bromobenzyl)-5-chlorobenzimidazol-2-yl]-3,3-dimethylbutanoate
CAS No.:144727-74-2
Molecular Formula:C₂₂H₂₃BrClFN₂O₂
Molecular Weight:481.792
Hs Code.:

Synonyms:ethyl 4-[1-(2-fluoro-4-bromobenzyl)-5-chlorobenzimidazol-2-yl]-3,3-dimethylbutanoate

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Chemical Property of ethyl 4-[1-(2-fluoro-4-bromobenzyl)-5-chlorobenzimidazol-2-yl]-3,3-dimethylbutanoate

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Technology Process of ethyl 4-[1-(2-fluoro-4-bromobenzyl)-5-chlorobenzimidazol-2-yl]-3,3-dimethylbutanoate

There total 5 articles about ethyl 4-[1-(2-fluoro-4-bromobenzyl)-5-chlorobenzimidazol-2-yl]-3,3-dimethylbutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 112734-22-2
4-bromo-2-fluorobenzylamine

: 144727-74-2
ethyl 4-[1-(2-fluoro-4-bromobenzyl)-5-chlorobenzimidazol-2-yl]-3,3-dimethylbutanoate

Guidance literature:: Multi-step reaction with 3 steps

1: 69 percent / 2 h / 135 °C

2: 91 percent / H₂ / Raney nickel / tetrahydrofuran / Ambient temperature

3: triethylamine / CHCl₃ / 2 h / Ambient temperature

With hydrogen; triethylamine; nickel; In tetrahydrofuran; chloroform;

Reference yield:

: 144728-13-2
(4-Bromo-2-fluoro-benzyl)-(4-chloro-2-nitro-phenyl)-amine

: 144727-74-2
ethyl 4-[1-(2-fluoro-4-bromobenzyl)-5-chlorobenzimidazol-2-yl]-3,3-dimethylbutanoate

Guidance literature:: Multi-step reaction with 2 steps

1: 91 percent / H₂ / Raney nickel / tetrahydrofuran / Ambient temperature

2: triethylamine / CHCl₃ / 2 h / Ambient temperature

With hydrogen; triethylamine; nickel; In tetrahydrofuran; chloroform;

Reference yield:

: 89-61-2
2,5-dichloronitrobenzene

: 144727-74-2
ethyl 4-[1-(2-fluoro-4-bromobenzyl)-5-chlorobenzimidazol-2-yl]-3,3-dimethylbutanoate

Guidance literature:: Multi-step reaction with 3 steps

1: 69 percent / 2 h / 135 °C

2: 91 percent / H₂ / Raney nickel / tetrahydrofuran / Ambient temperature

3: triethylamine / CHCl₃ / 2 h / Ambient temperature

With hydrogen; triethylamine; nickel; In tetrahydrofuran; chloroform;