7-HYDROXY-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE

Base Information

• Chemical Name: 7-HYDROXY-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE
• CAS No.: 22246-05-5
• Molecular Formula: C9H9 N O2
• Molecular Weight: 163.176
• Hs Code.: 2933499090
• Mol file: 22246-05-5.mol

Synonyms:Isocarbostyril,3,4-dihydro-7-hydroxy- (8CI); 7-Hydroxy-3,4-dihydro-2H-isoquinolin-1-one

Chemical Property of 7-HYDROXY-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE

Chemical Property:

• PSA: 49.33000
• Density: 1.282
• LogP: 1.00690
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

99%, ^*data from raw suppliers

7-Hydroxy-3,4-dihydro-2H-isoquinolin-1-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 7-Hydroxy-3,4-dihydro-2H-isoquinolin-1-one?is used in preparation of amine compound as SSAO/VAP-1 inhibitor.

Technology Process of 7-HYDROXY-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE

There total 13 articles about 7-HYDROXY-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

7-methoxy-3,4-dihydro-2H-isoquinolin-1-one (22246-04-4) → 7-hydroxy-3,4-dihydro-1-oxo-2(1H)-isoquinoline (22246-05-5)

Guidance literature:

With boron tribromide; In dichloromethane; at 0 - 30 ℃; for 2h; Inert atmosphere;

Reference yield: 84.0%

4-hydroxyphenyl-2-ethylcarbamic acid methyl ester (62372-08-1) → 7-hydroxy-3,4-dihydro-1-oxo-2(1H)-isoquinoline (22246-05-5)

Guidance literature:

With trifluorormethanesulfonic acid; at 0 - 70 ℃; for 28h;

DOI:10.1021/jo3020566

Reference yield: 82.0%

2-4-methoxyphenylethylcarbamic acid methyl ester (91247-71-1) → 7-hydroxy-3,4-dihydro-1-oxo-2(1H)-isoquinoline (22246-05-5)

Guidance literature:

With trifluorormethanesulfonic acid; at 0 - 70 ℃; for 29h;

DOI:10.1021/jo3020566

upstream raw materials:

7-methoxy-3,4-dihydro-2H-isoquinolin-1-one

6-methoxy-2,3-dihydro-1H-inden-1-one

2-4-methoxyphenylethylcarbamic acid methyl ester

4-hydroxyphenyl-2-ethylcarbamic acid methyl ester

Downstream raw materials:

7-(benzyloxy)-3,4-dihydroisoquinolin-1(2H)-one

(7-Benzyloxy-1-oxo-3,4-dihydro-1H-isoquinolin-2-yl)-acetic acid tert-butyl ester

[7-(4-Cyano-benzyloxy)-1-oxo-3,4-dihydro-1H-isoquinolin-2-yl]-acetic acid tert-butyl ester

{6-[2-(4-Carbamimidoyl-phenyl)-ethoxy]-1-oxo-3,4-dihydro-1H-isoquinolin-2-yl}-acetic acid tert-butyl ester

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