1-Biphenyl-2-yl-3-(1-{9-[2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethylamino]nonyl}piperidin-4-yl)urea

Base Information

Chemical Name:1-Biphenyl-2-yl-3-(1-{9-[2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethylamino]nonyl}piperidin-4-yl)urea
CAS No.:743460-09-5
Molecular Formula:C₃₈H₄₉N₅O₄
Molecular Weight:639.838
Hs Code.:

Synonyms:1-Biphenyl-2-yl-3-(1-{9-[2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethylamino]nonyl}piperidin-4-yl)urea

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Chemical Property of 1-Biphenyl-2-yl-3-(1-{9-[2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethylamino]nonyl}piperidin-4-yl)urea

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Technology Process of 1-Biphenyl-2-yl-3-(1-{9-[2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethylamino]nonyl}piperidin-4-yl)urea

There total 10 articles about 1-Biphenyl-2-yl-3-(1-{9-[2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethylamino]nonyl}piperidin-4-yl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 55362-80-6
9-bromononan-1-ol

: 743460-09-5
1-Biphenyl-2-yl-3-(1-{9-[2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethylamino]nonyl}piperidin-4-yl)urea

Guidance literature:: Multi-step reaction with 6 steps

1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 50 °C

2: sulfur trioxide pyridine complex; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine / dichloromethane / 0 °C

3: sodium tris(acetoxy)borohydride / methanol; dichloromethane

4: 20 % Pd(OH)2/C; hydrogen / ethanol

5: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane

6: 10% palladium on activated charcoal; hydrogen / methanol

With 10% palladium on activated charcoal; 20 % Pd(OH)2/C; hydrogen; sulfur trioxide pyridine complex; sodium tris(acetoxy)borohydride; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; In methanol; ethanol; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2011.01.043

Reference yield:

: 17337-13-2
[1,1'-biphenyl]-2-yl-isocyanate

: 743460-09-5
1-Biphenyl-2-yl-3-(1-{9-[2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethylamino]nonyl}piperidin-4-yl)urea

Guidance literature:: Multi-step reaction with 8 steps

1: 70 °C / neat (no solvent)

2: 10% palladium on activated charcoal; ammonium bicarbonate / ethanol / 40 °C

3: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 50 °C

4: sulfur trioxide pyridine complex; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine / dichloromethane / 0 °C

5: sodium tris(acetoxy)borohydride / methanol; dichloromethane

6: 20 % Pd(OH)2/C; hydrogen / ethanol

7: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane

8: 10% palladium on activated charcoal; hydrogen / methanol

With 10% palladium on activated charcoal; 20 % Pd(OH)2/C; hydrogen; sulfur trioxide pyridine complex; sodium tris(acetoxy)borohydride; ammonium bicarbonate; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; In methanol; ethanol; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2011.01.043