2-({3-fluoro-2-(2-fluoropyridin-3-yl)-4-[(methylamino)methyl]-1H-pyrrol-1-yl}sulfonyl)benzonitrile hydrochloride

Base Information

Chemical Name:2-({3-fluoro-2-(2-fluoropyridin-3-yl)-4-[(methylamino)methyl]-1H-pyrrol-1-yl}sulfonyl)benzonitrile hydrochloride
CAS No.:1055305-93-5
Molecular Formula:C₁₈H₁₄F₂N₄O₂S*ClH
Molecular Weight:424.859
Hs Code.:

Synonyms:2-({3-fluoro-2-(2-fluoropyridin-3-yl)-4-[(methylamino)methyl]-1H-pyrrol-1-yl}sulfonyl)benzonitrile hydrochloride

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Chemical Property of 2-({3-fluoro-2-(2-fluoropyridin-3-yl)-4-[(methylamino)methyl]-1H-pyrrol-1-yl}sulfonyl)benzonitrile hydrochloride

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Technology Process of 2-({3-fluoro-2-(2-fluoropyridin-3-yl)-4-[(methylamino)methyl]-1H-pyrrol-1-yl}sulfonyl)benzonitrile hydrochloride

There total 11 articles about 2-({3-fluoro-2-(2-fluoropyridin-3-yl)-4-[(methylamino)methyl]-1H-pyrrol-1-yl}sulfonyl)benzonitrile hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1055307-45-3
tert-butyl {[1-[(2-cyanophenyl)sulfonyl]-4-fluoro-5-(2-fluoropyridin-3-yl)-1H-pyrrol-3-yl]methyl}methylcarbamate

: 1055305-93-5
2-({3-fluoro-2-(2-fluoropyridin-3-yl)-4-[(methylamino)methyl]-1H-pyrrol-1-yl}sulfonyl)benzonitrile hydrochloride

Guidance literature:: With hydrogenchloride; ethanol; In ethyl acetate; at 20 ℃; for 2h;

Reference yield:

: 1055306-63-2
tert-butyl (4RS)-4-(bromomethyl)-3,3-difluoro-2-oxopyrrolidine-1-carboxylate

: 1055305-93-5
2-({3-fluoro-2-(2-fluoropyridin-3-yl)-4-[(methylamino)methyl]-1H-pyrrol-1-yl}sulfonyl)benzonitrile hydrochloride

Guidance literature:: Multi-step reaction with 10 steps

1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 1.25 h / 0 - 20 °C

2.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 2.75 h / -78 °C

2.2: 3 h / -78 °C

3.1: hydrogenchloride; water; acetic acid / 1 h / 20 °C

4.1: sodium hydride / tetrahydrofuran / 18 h / 0 - 60 °C

4.2: 1 h / 0 °C

5.1: sodium hydride / tetrahydrofuran / 0.17 h / 0 °C

5.2: 0.17 h / 0 °C

5.3: 0.25 h / 0 °C

6.1: carbonochloridic acid 1-chloro-ethyl ester / tetrahydrofuran / 0.25 h / 0 °C

6.2: 16 h / 65 °C

6.3: 0.17 h / 20 °C

7.1: tetrahydrofuran / 0.08 h / 20 °C

8.1: sodium hydroxide; water; isopropyl alcohol / tetrahydrofuran / 18 h / 0 - 20 °C

9.1: 15-crown-5; sodium hydride / tetrahydrofuran / 0.5 h / 0 °C

10.1: hydrogenchloride; ethanol / ethyl acetate / 2 h / 20 °C

With hydrogenchloride; sodium hydroxide; n-butyllithium; 15-crown-5; ethanol; carbonochloridic acid 1-chloro-ethyl ester; water; sodium hydride; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; diisopropylamine; isopropyl alcohol; In tetrahydrofuran; hexane; ethyl acetate;

Reference yield:

: 3-(4,4-difluoro-3-methylidene-3,4-dihydro-2H-pyrrol-5-yl)-2-fluoropyridine

: 1055305-93-5
2-({3-fluoro-2-(2-fluoropyridin-3-yl)-4-[(methylamino)methyl]-1H-pyrrol-1-yl}sulfonyl)benzonitrile hydrochloride

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hydride / tetrahydrofuran / 18 h / 0 - 60 °C

1.2: 1 h / 0 °C

2.1: sodium hydride / tetrahydrofuran / 0.17 h / 0 °C

2.2: 0.17 h / 0 °C

2.3: 0.25 h / 0 °C

3.1: carbonochloridic acid 1-chloro-ethyl ester / tetrahydrofuran / 0.25 h / 0 °C

3.2: 16 h / 65 °C

3.3: 0.17 h / 20 °C

4.1: tetrahydrofuran / 0.08 h / 20 °C

5.1: sodium hydroxide; water; isopropyl alcohol / tetrahydrofuran / 18 h / 0 - 20 °C

6.1: 15-crown-5; sodium hydride / tetrahydrofuran / 0.5 h / 0 °C

7.1: hydrogenchloride; ethanol / ethyl acetate / 2 h / 20 °C

With hydrogenchloride; sodium hydroxide; 15-crown-5; ethanol; carbonochloridic acid 1-chloro-ethyl ester; water; sodium hydride; isopropyl alcohol; In tetrahydrofuran; ethyl acetate;