tert-butyl 3-(3-((4-methoxy-6-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2-ylamino)methyl)phenoxy)propylcarbamate

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Chemical Name:tert-butyl 3-(3-((4-methoxy-6-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2-ylamino)methyl)phenoxy)propylcarbamate
CAS No.:1341213-50-0
Molecular Formula:C₂₇H₃₂N₆O₄
Molecular Weight:504.589
Hs Code.:

Synonyms:tert-butyl 3-(3-((4-methoxy-6-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2-ylamino)methyl)phenoxy)propylcarbamate

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Chemical Property of tert-butyl 3-(3-((4-methoxy-6-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2-ylamino)methyl)phenoxy)propylcarbamate

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Technology Process of tert-butyl 3-(3-((4-methoxy-6-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2-ylamino)methyl)phenoxy)propylcarbamate

There total 4 articles about tert-butyl 3-(3-((4-methoxy-6-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2-ylamino)methyl)phenoxy)propylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1341213-49-7
tert-butyl 3-(3-((4-methoxy-6-(1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2-ylamino)methyl)phenoxy)propylcarbamate

: 1341213-50-0
tert-butyl 3-(3-((4-methoxy-6-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2-ylamino)methyl)phenoxy)propylcarbamate

Guidance literature:: With water; sodium hydroxide; In methanol; at 20 ℃; for 16h;

Reference yield:

: 89466-42-2
4-chloro-6-methoxy-2-(methylsulfanyl)pyrimidine

: 1341213-50-0
tert-butyl 3-(3-((4-methoxy-6-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2-ylamino)methyl)phenoxy)propylcarbamate

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; 1,2-dimethoxyethane / 0.33 h / 85 °C / Inert atmosphere

2: OXONE_.(R). / ethyl acetate / 48 h / 77 °C

3: triethylamine / 1,4-dioxane / 100 °C

4: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 3 h / 20 °C

5: sodium hydroxide; water / methanol / 16 h / 20 °C

With di-isopropyl azodicarboxylate; water; potassium carbonate; triethylamine; triphenylphosphine; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; 1,2-dimethoxyethane; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 1262293-71-9
3-(6-methoxy-2-(methylthio)pyrimidin-4-yl)-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine

: 1341213-50-0
tert-butyl 3-(3-((4-methoxy-6-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2-ylamino)methyl)phenoxy)propylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1: OXONE_.(R). / ethyl acetate / 48 h / 77 °C

2: triethylamine / 1,4-dioxane / 100 °C

3: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 3 h / 20 °C

4: sodium hydroxide; water / methanol / 16 h / 20 °C

With di-isopropyl azodicarboxylate; water; triethylamine; triphenylphosphine; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; ethyl acetate;