(R)-1-(1-bromopropan-2-yl)-4-methylbenzene

Base Information

• Chemical Name: (R)-1-(1-bromopropan-2-yl)-4-methylbenzene
• CAS No.: 503543-30-4
• Molecular Formula: C₁₀H₁₃Br
• Molecular Weight: 213.117
• Mol file: 503543-30-4.mol

Synonyms:(R)-1-(1-bromopropan-2-yl)-4-methylbenzene

Chemical Property of (R)-1-(1-bromopropan-2-yl)-4-methylbenzene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-1-(1-bromopropan-2-yl)-4-methylbenzene

There total 3 articles about (R)-1-(1-bromopropan-2-yl)-4-methylbenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

para-methylphenylmagnesium bromide (4294-57-9) → (R)-1-(1-bromopropan-2-yl)-4-methylbenzene (503543-30-4)

Guidance literature:

Multi-step reaction with 3 steps

1: cobalt(II) iodide; (4R,4’R)-2,2’-(propane-2,2-diyl)bis(4-benzyl-4,5-dihydrooxazole) / tetrahydrofuran / 10 h / -78 °C / Schlenk technique; Inert atmosphere

2: diisobutylaluminium hydride / dichloromethane; toluene / 1 h / -78 - 0 °C / Inert atmosphere

3: triphenylphosphine; carbon tetrabromide / dichloromethane / 4 h / 25 °C / Inert atmosphere

With carbon tetrabromide; diisobutylaluminium hydride; (4R,4’R)-2,2’-(propane-2,2-diyl)bis(4-benzyl-4,5-dihydrooxazole); triphenylphosphine; cobalt(II) iodide; In tetrahydrofuran; dichloromethane; toluene; 1: |Kumada Cross-Coupling;

DOI:10.1016/j.tetasy.2015.11.009

Reference yield:

(R)-benzyl 2-p-tolylpropanoate → (R)-1-(1-bromopropan-2-yl)-4-methylbenzene (503543-30-4)

Guidance literature:

Multi-step reaction with 2 steps

1: diisobutylaluminium hydride / dichloromethane; toluene / 1 h / -78 - 0 °C / Inert atmosphere

2: triphenylphosphine; carbon tetrabromide / dichloromethane / 4 h / 25 °C / Inert atmosphere

With carbon tetrabromide; diisobutylaluminium hydride; triphenylphosphine; In dichloromethane; toluene;

DOI:10.1016/j.tetasy.2015.11.009

Reference yield:

1-methyl-4-isopropenylbenzene (1195-32-0) → (R)-1-(1-bromopropan-2-yl)-4-methylbenzene (503543-30-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: AD-mix-α; H2O / 2-methyl-propan-2-ol / 18 h / 0 °C

1.2: ethanol / Raney Ni / 3 h / Heating

2.1: 99 percent / PPh₃; CBr₄ / CH₂Cl₂ / 4 h / 20 °C

With AD-mix-α; carbon tetrabromide; water; triphenylphosphine; In dichloromethane; tert-butyl alcohol; 1.1: Sharpless reaction;

DOI:10.1016/S0957-4166(02)00759-0

upstream raw materials:

1-methyl-4-isopropenylbenzene

para-methylphenylmagnesium bromide

Downstream raw materials:

(+)-(7S,9R)-ar-turmerol

(+)-(7S,9S)-ar-turmerol

(S)-4-p-tolylpentanal

(S)-curcumene