N-(2-iodo-4-methylphenyl)-N-benzyl-(α-deuterio)cinnamide

Base Information

• Chemical Name: N-(2-iodo-4-methylphenyl)-N-benzyl-(α-deuterio)cinnamide
• CAS No.: 370558-37-5
• Molecular Formula: C₂₃H₂₀INO
• Molecular Weight: 454.314
• Mol file: 370558-37-5.mol

Synonyms:N-(2-iodo-4-methylphenyl)-N-benzyl-(α-deuterio)cinnamide

Chemical Property of N-(2-iodo-4-methylphenyl)-N-benzyl-(α-deuterio)cinnamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(2-iodo-4-methylphenyl)-N-benzyl-(α-deuterio)cinnamide

There total 7 articles about N-(2-iodo-4-methylphenyl)-N-benzyl-(α-deuterio)cinnamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl (α-deuterio)cinnamate (55836-65-2) → N-(2-iodo-4-methylphenyl)-N-benzyl-(α-deuterio)cinnamide (370558-37-5)

Guidance literature:

Multi-step reaction with 4 steps

1: aq. NaOH / Heating

2: SOCl₂

3: 1.72 g / NaH / dimethylformamide

With sodium hydroxide; thionyl chloride; sodium hydride; In N,N-dimethyl-formamide;

DOI:10.1039/b100418m

Reference yield:

(Z)-methyl 2-bromo-3-phenylacrylate (21788-36-3) → N-(2-iodo-4-methylphenyl)-N-benzyl-(α-deuterio)cinnamide (370558-37-5)

Guidance literature:

Multi-step reaction with 5 steps

1: Bu₃SnD; AIBN / toluene / 8 h

2: aq. NaOH / Heating

3: SOCl₂

4: 1.72 g / NaH / dimethylformamide

With sodium hydroxide; thionyl chloride; 2,2'-azobis(isobutyronitrile); sodium hydride; tributyltin deuteride; In N,N-dimethyl-formamide; toluene;

DOI:10.1039/b100418m

Reference yield:

α-deuteriocinnamic acid (42198-68-5) → N-(2-iodo-4-methylphenyl)-N-benzyl-(α-deuterio)cinnamide (370558-37-5)

Guidance literature:

Multi-step reaction with 3 steps

1: SOCl₂

2: 1.72 g / NaH / dimethylformamide

With thionyl chloride; sodium hydride; In N,N-dimethyl-formamide;

DOI:10.1039/b100418m

upstream raw materials:

benzyl bromide

methyl (α-deuterio)cinnamate

(Z)-methyl 2-bromo-3-phenylacrylate

α-deuteriocinnamic acid

Downstream raw materials:

1,3-dibenzyl-5-methylindolin-2-one

3-hydroxy-1,3-dibenzyl-5-methylindolin-2-one