Technology Process of (S,E)-ethyl 4-hydroxy-4-((S)-hydroxy(phenyl)methyl)pent-2-enoate
There total 2 articles about (S,E)-ethyl 4-hydroxy-4-((S)-hydroxy(phenyl)methyl)pent-2-enoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
osmium(VIII) oxide; DHQ-2-Me-2-Quin; potassium hexacyanoferrate(III);
methanesulfonamide; potassium carbonate;
In
tert-butyl alcohol;
at 0 ℃;
for 8h;
Title compound not separated from byproducts;
DOI:10.1021/jo061200h
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 90 percent / CH2Cl2 / 20 °C
2: OsO4; DHQ-2-Me-2-Quin; K3Fe(CN)6 / K2CO3; MeSO2NH2 / 2-methyl-propan-2-ol; various solvent(s) / 8 h / 0 °C
With
osmium(VIII) oxide; DHQ-2-Me-2-Quin; potassium hexacyanoferrate(III);
methanesulfonamide; potassium carbonate;
In
dichloromethane; tert-butyl alcohol;
2: Sharpless dihydroxylation;
DOI:10.1021/jo061200h
- Guidance literature:
-
Multi-step reaction with 3 steps
1: pyridine / CH2Cl2 / 0.08 h / 0 °C
2: HCO2H; PPh3; Et3N / Pd2(dba)3*CHCl3 / tetrahydrofuran / 0.17 h / Heating
3: t-BuOK / tetrahydrofuran / 1.5 h / 0 °C
With
pyridine; formic acid; potassium tert-butylate; triethylamine; triphenylphosphine;
tris(dibenzylideneacetone)dipalladium(0) chloroform complex;
In
tetrahydrofuran; dichloromethane;
DOI:10.1021/jo061200h