Technology Process of (2S,3R,4S,5S,7S)-2,3-dihydroxy-7-benzyl-cephalotaxan-8-one
There total 12 articles about (2S,3R,4S,5S,7S)-2,3-dihydroxy-7-benzyl-cephalotaxan-8-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogenchloride; water;
In
tetrahydrofuran;
at 50 ℃;
for 0.5h;
DOI:10.1021/jo049884l
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: 98 percent / hexamethyldisilazane / CH2Cl2 / 17 h / 0 - 20 °C
2.1: 85 percent / palladium(II) acetate / acetonitrile / 16 h / 20 °C
3.1: Al(i-PrO)3 / 0.75 h / 130 - 140 °C
4.1: 550 mg / SnCl4 / CH2Cl2; nitromethane / 4 h / -78 - 20 °C
5.1: 81 percent / NMO; H2O / OsO4 / tetrahydrofuran; 2-methyl-propan-2-ol / 24 h / 20 °C
6.1: 86 percent / p-toluenesulfonic acid / 4 h / 20 °C
7.1: s-BuLi / tetrahydrofuran; cyclohexane / 0.33 h / -78 °C
7.2: 71 percent / tetrahydrofuran; cyclohexane / 1 h / cooling
8.1: 100 percent / HCl; H2O / tetrahydrofuran / 0.5 h / 50 °C
With
hydrogenchloride; N-methyl-2-indolinone; water; sec.-butyllithium; palladium diacetate; tin(IV) chloride; aluminum isopropoxide; toluene-4-sulfonic acid; 1,1,1,3,3,3-hexamethyl-disilazane;
osmium(VIII) oxide;
In
tetrahydrofuran; nitromethane; dichloromethane; cyclohexane; acetonitrile; tert-butyl alcohol;
DOI:10.1021/jo049884l
- Guidance literature:
-
Multi-step reaction with 11 steps
1.1: 100 percent / lithium; ammonia / tetrahydrofuran / -78 - 20 °C
2.1: 80 percent / NaH / benzene / 16 h / Heating
3.1: 100 percent / acetic acid; water / 16 h / Heating
4.1: 98 percent / hexamethyldisilazane / CH2Cl2 / 17 h / 0 - 20 °C
5.1: 85 percent / palladium(II) acetate / acetonitrile / 16 h / 20 °C
6.1: Al(i-PrO)3 / 0.75 h / 130 - 140 °C
7.1: 550 mg / SnCl4 / CH2Cl2; nitromethane / 4 h / -78 - 20 °C
8.1: 81 percent / NMO; H2O / OsO4 / tetrahydrofuran; 2-methyl-propan-2-ol / 24 h / 20 °C
9.1: 86 percent / p-toluenesulfonic acid / 4 h / 20 °C
10.1: s-BuLi / tetrahydrofuran; cyclohexane / 0.33 h / -78 °C
10.2: 71 percent / tetrahydrofuran; cyclohexane / 1 h / cooling
11.1: 100 percent / HCl; H2O / tetrahydrofuran / 0.5 h / 50 °C
With
hydrogenchloride; N-methyl-2-indolinone; ammonia; water; sec.-butyllithium; palladium diacetate; tin(IV) chloride; aluminum isopropoxide; lithium; sodium hydride; toluene-4-sulfonic acid; acetic acid; 1,1,1,3,3,3-hexamethyl-disilazane;
osmium(VIII) oxide;
In
tetrahydrofuran; nitromethane; dichloromethane; cyclohexane; acetonitrile; tert-butyl alcohol; benzene;
DOI:10.1021/jo049884l
