2-chloro-5-fluoro-4-(6-fluoro-11-methyl-2,3-dihydro-9H-[1,4]dioxino[2,3-f]pyrazolo[3,4-c]isoquinolin-7-yl)phenol

Base Information

Chemical Name:2-chloro-5-fluoro-4-(6-fluoro-11-methyl-2,3-dihydro-9H-[1,4]dioxino[2,3-f]pyrazolo[3,4-c]isoquinolin-7-yl)phenol
CAS No.:838857-77-5
Molecular Formula:C₁₉H₁₂ClF₂N₃O₃
Molecular Weight:403.772
Hs Code.:

Synonyms:2-chloro-5-fluoro-4-(6-fluoro-11-methyl-2,3-dihydro-9H-[1,4]dioxino[2,3-f]pyrazolo[3,4-c]isoquinolin-7-yl)phenol

Suppliers and Price of 2-chloro-5-fluoro-4-(6-fluoro-11-methyl-2,3-dihydro-9H-[1,4]dioxino[2,3-f]pyrazolo[3,4-c]isoquinolin-7-yl)phenol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-chloro-5-fluoro-4-(6-fluoro-11-methyl-2,3-dihydro-9H-[1,4]dioxino[2,3-f]pyrazolo[3,4-c]isoquinolin-7-yl)phenol

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-chloro-5-fluoro-4-(6-fluoro-11-methyl-2,3-dihydro-9H-[1,4]dioxino[2,3-f]pyrazolo[3,4-c]isoquinolin-7-yl)phenol

There total 3 articles about 2-chloro-5-fluoro-4-(6-fluoro-11-methyl-2,3-dihydro-9H-[1,4]dioxino[2,3-f]pyrazolo[3,4-c]isoquinolin-7-yl)phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 4.2%

: 838856-31-8
5-chloro-2-fluoro-4-hydroxybenzaldehyde

: 838857-84-4
4-(7-fluoro-2,3-dihydro-1,4-benzodioxin-5-yl)-3-methyl-1H-pyrazol-5-amine

: 838857-77-5
2-chloro-5-fluoro-4-(6-fluoro-11-methyl-2,3-dihydro-9H-[1,4]dioxino[2,3-f]pyrazolo[3,4-c]isoquinolin-7-yl)phenol

Guidance literature:: With trifluoroacetic acid; at 75 ℃; for 12h;

Reference yield:

: 819800-84-5
methyl 7-fluoro-2,3-dihydrobenzo[b][1,4]dioxine-5-carboxylate

: 838857-77-5
2-chloro-5-fluoro-4-(6-fluoro-11-methyl-2,3-dihydro-9H-[1,4]dioxino[2,3-f]pyrazolo[3,4-c]isoquinolin-7-yl)phenol

Guidance literature:: Multi-step reaction with 6 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 0.75 h / 0 - 20 °C

2: thionyl chloride; triethylamine / dichloromethane / 0.75 h / 0 °C

3: N,N-dimethyl-formamide / 5 h / 60 °C

4: sodium hydride / tetrahydrofuran / 1 h / Heating / reflux

5: hydrazine dihydrochloride / ethanol / 3.5 h / Heating / reflux

6: trifluoroacetic acid / 12 h / 75 °C

With lithium aluminium tetrahydride; thionyl chloride; hydrazine dihydrochloride; sodium hydride; triethylamine; trifluoroacetic acid; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 838857-82-2
(7-fluoro-2,3-dihydro-1,4-benzodioxin-5-yl)acetonitrile

: 838857-77-5
2-chloro-5-fluoro-4-(6-fluoro-11-methyl-2,3-dihydro-9H-[1,4]dioxino[2,3-f]pyrazolo[3,4-c]isoquinolin-7-yl)phenol

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydride / tetrahydrofuran / 1 h / Heating / reflux

2: hydrazine dihydrochloride / ethanol / 3.5 h / Heating / reflux

3: trifluoroacetic acid / 12 h / 75 °C

With hydrazine dihydrochloride; sodium hydride; trifluoroacetic acid; In tetrahydrofuran; ethanol;