tert-butyl (R)-3-(4-chloro-3-fluorophenyl)-1-((S)-4-((5R,7R)-7-methoxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)-3-methylpiperazin-1-yl)-1-oxopropan-2-ylcarbamate

Base Information

Chemical Name:tert-butyl (R)-3-(4-chloro-3-fluorophenyl)-1-((S)-4-((5R,7R)-7-methoxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)-3-methylpiperazin-1-yl)-1-oxopropan-2-ylcarbamate
CAS No.:1001270-18-3
Molecular Formula:C₂₈H₃₇ClFN₅O₄
Molecular Weight:562.084
Hs Code.:

tert-butyl (R)-3-(4-chloro-3-fluorophenyl)-1-((S)-4-((5R,7R)-7-methoxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)-3-methylpiperazin-1-yl)-1-oxopropan-2-ylcarbamate

Synonyms:tert-butyl (R)-3-(4-chloro-3-fluorophenyl)-1-((S)-4-((5R,7R)-7-methoxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)-3-methylpiperazin-1-yl)-1-oxopropan-2-ylcarbamate

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Chemical Property of tert-butyl (R)-3-(4-chloro-3-fluorophenyl)-1-((S)-4-((5R,7R)-7-methoxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)-3-methylpiperazin-1-yl)-1-oxopropan-2-ylcarbamate

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Technology Process of tert-butyl (R)-3-(4-chloro-3-fluorophenyl)-1-((S)-4-((5R,7R)-7-methoxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)-3-methylpiperazin-1-yl)-1-oxopropan-2-ylcarbamate

There total 14 articles about tert-butyl (R)-3-(4-chloro-3-fluorophenyl)-1-((S)-4-((5R,7R)-7-methoxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)-3-methylpiperazin-1-yl)-1-oxopropan-2-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1001270-12-7
(R)-2-(tert-butoxycarbonyl)-3-(4-chloro-3-fluorophenyl)-propanoic acid

: (5R,7R)-7-methoxy-5-methyl-4-((S)-2-methylpiperazin-1-yl)-6,7-dihydro-5H-cyclopenta[d]pyrimidine dihydrochloride

: 1001270-18-3
tert-butyl (R)-3-(4-chloro-3-fluorophenyl)-1-((S)-4-((5R,7R)-7-methoxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)-3-methylpiperazin-1-yl)-1-oxopropan-2-ylcarbamate

Guidance literature:: With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In dichloromethane; at 20 ℃; for 1h;

Reference yield:

: 681467-09-4
(2R)-ethyl 2-methyl-5-(propan-2-ylidene)cyclopentanecarboxylate

: 1001270-18-3
tert-butyl (R)-3-(4-chloro-3-fluorophenyl)-1-((S)-4-((5R,7R)-7-methoxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)-3-methylpiperazin-1-yl)-1-oxopropan-2-ylcarbamate

Guidance literature:: Multi-step reaction with 11 steps

1.1: ozone / ethyl acetate / -78 °C

1.2: 2.5 h / 0 °C

2.1: ammonium acetate / methanol / 20 h / 20 °C

3.1: 17 h / 150 °C

4.1: trichlorophosphate / 0.08 h / Heating / reflux

5.1: 3-chloro-benzenecarboperoxoic acid / chloroform / 48 h / 20 °C

5.2: 0.33 h / 0 °C

6.1: 2 h / 110 °C

7.1: 1-methyl-pyrrolidin-2-one / 60 h / 125 °C

8.1: lithium hydroxide; water / tetrahydrofuran / 6 h / 20 °C

9.1: sodium hydride / tetrahydrofuran / 20 °C

10.1: hydrogenchloride / 1,4-dioxane; dichloromethane / 10 h

11.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine / dichloromethane / 1 h / 20 °C

With hydrogenchloride; lithium hydroxide; ammonium acetate; water; sodium hydride; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; ozone; triethylamine; 3-chloro-benzenecarboperoxoic acid; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one; methanol; dichloromethane; chloroform; ethyl acetate;

Reference yield:

: 623935-92-2
ethyl (2R)-2-methyl-5-(propan-2-ylidene)cyclopentanecarboxylate

: 1001270-18-3
tert-butyl (R)-3-(4-chloro-3-fluorophenyl)-1-((S)-4-((5R,7R)-7-methoxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)-3-methylpiperazin-1-yl)-1-oxopropan-2-ylcarbamate

Guidance literature:: Multi-step reaction with 11 steps

1.1: ozone / ethyl acetate / 3.5 h / -68 °C

1.2: 0.5 h / 0 °C

2.1: ammonium acetate / methanol / 20 h / 20 °C

3.1: 17 h / 150 °C

4.1: trichlorophosphate / 0.08 h / Heating / reflux

5.1: 3-chloro-benzenecarboperoxoic acid / chloroform / 48 h / 20 °C

5.2: 0.33 h / 0 °C

6.1: 2 h / 110 °C

7.1: 1-methyl-pyrrolidin-2-one / 60 h / 125 °C

8.1: lithium hydroxide; water / tetrahydrofuran / 6 h / 20 °C

9.1: sodium hydride / tetrahydrofuran / 20 °C

10.1: hydrogenchloride / 1,4-dioxane; dichloromethane / 10 h

11.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine / dichloromethane / 1 h / 20 °C

With hydrogenchloride; lithium hydroxide; ammonium acetate; water; sodium hydride; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; ozone; triethylamine; 3-chloro-benzenecarboperoxoic acid; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one; methanol; dichloromethane; chloroform; ethyl acetate;