1-[(4-triphenylphosphoranylideneamino)butanoyl]-4-(1,3-bis(dihydroxyphosphoryloxy)propan-2-yloxy)-7-nitroindoline

Base Information

Chemical Name:1-[(4-triphenylphosphoranylideneamino)butanoyl]-4-(1,3-bis(dihydroxyphosphoryloxy)propan-2-yloxy)-7-nitroindoline
CAS No.:927812-47-3
Molecular Formula:C₃₃H₃₆N₃O₁₂P₃
Molecular Weight:759.583
Hs Code.:

Synonyms:1-[(4-triphenylphosphoranylideneamino)butanoyl]-4-(1,3-bis(dihydroxyphosphoryloxy)propan-2-yloxy)-7-nitroindoline

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Chemical Property of 1-[(4-triphenylphosphoranylideneamino)butanoyl]-4-(1,3-bis(dihydroxyphosphoryloxy)propan-2-yloxy)-7-nitroindoline

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Technology Process of 1-[(4-triphenylphosphoranylideneamino)butanoyl]-4-(1,3-bis(dihydroxyphosphoryloxy)propan-2-yloxy)-7-nitroindoline

There total 9 articles about 1-[(4-triphenylphosphoranylideneamino)butanoyl]-4-(1,3-bis(dihydroxyphosphoryloxy)propan-2-yloxy)-7-nitroindoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1-(4-azidobutanoyl)-4-[1,3-bis(dihydroxyphosphoryloxy)propan-2-yloxy]-7-nitroindoline tetrasodium salt

: 603-35-0
triphenylphosphine

: 927812-47-3
1-[(4-triphenylphosphoranylideneamino)butanoyl]-4-(1,3-bis(dihydroxyphosphoryloxy)propan-2-yloxy)-7-nitroindoline

Guidance literature:: In water; N,N-dimethyl-formamide; at 20 ℃; for 20h;

Reference yield:

: 868947-76-6
diethyl 2-(indol-4-yloxy)malonate

: 927812-47-3
1-[(4-triphenylphosphoranylideneamino)butanoyl]-4-(1,3-bis(dihydroxyphosphoryloxy)propan-2-yloxy)-7-nitroindoline

Guidance literature:: Multi-step reaction with 8 steps

1: LiAlH₄ / diethyl ether / 2 h / Heating

2: 80 percent / pyridine / 20 °C

3: acetic acid; NaBH₃CN / 1 h / 20 °C

4: 64 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / acetonitrile / 20 °C

5: 70 percent / copper(II) nitrate; acetic anhydride / CH₂Cl₂ / 20 °C

6: 78 percent / aq. NaOH / methanol / 0.03 h / 20 °C

7: pyrophosphoryl chloride / ethyl acetate / 3 h / 0 °C

8: H₂O; dimethylformamide / 20 h / 20 °C

With pyridine; sodium hydroxide; lithium aluminium tetrahydride; pyrophosphoryl chloride; acetic anhydride; sodium cyanoborohydride; copper(II) nitrate; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; diethyl ether; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.tet.2007.07.030

Reference yield:

: 927812-45-1
1-(4-azidobutanoyl)-4-(1,3-dihydroxypropan-2-yloxy)-7-nitroindoline

: 927812-47-3
1-[(4-triphenylphosphoranylideneamino)butanoyl]-4-(1,3-bis(dihydroxyphosphoryloxy)propan-2-yloxy)-7-nitroindoline

Guidance literature:: Multi-step reaction with 2 steps

1: pyrophosphoryl chloride / ethyl acetate / 3 h / 0 °C

2: H₂O; dimethylformamide / 20 h / 20 °C

With pyrophosphoryl chloride; In water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2007.07.030