methyl 3(R)-<<<1-<(benzyloxy)acetyl>-2(S)-pyrrolidinyl>carbonyl>amino>-2-oxo-1-pyrrolidineacetate

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Chemical Name:methyl 3(R)-<<<1-<(benzyloxy)acetyl>-2(S)-pyrrolidinyl>carbonyl>amino>-2-oxo-1-pyrrolidineacetate
CAS No.:158268-46-3
Molecular Formula:C₂₁H₂₇N₃O₆
Molecular Weight:417.462
Hs Code.:

Synonyms:methyl 3(R)-<<<1-<(benzyloxy)acetyl>-2(S)-pyrrolidinyl>carbonyl>amino>-2-oxo-1-pyrrolidineacetate

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Chemical Property of methyl 3(R)-<<<1-<(benzyloxy)acetyl>-2(S)-pyrrolidinyl>carbonyl>amino>-2-oxo-1-pyrrolidineacetate

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Technology Process of methyl 3(R)-<<<1-<(benzyloxy)acetyl>-2(S)-pyrrolidinyl>carbonyl>amino>-2-oxo-1-pyrrolidineacetate

There total 5 articles about methyl 3(R)-<<<1-<(benzyloxy)acetyl>-2(S)-pyrrolidinyl>carbonyl>amino>-2-oxo-1-pyrrolidineacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 158268-45-2
N-<(benzyloxy)acetyl>-L-proline

: ((R)-3-Amino-2-oxo-pyrrolidin-1-yl)-acetic acid methyl ester; hydrochloride

: 158268-46-3
methyl 3(R)-<<<1-<(benzyloxy)acetyl>-2(S)-pyrrolidinyl>carbonyl>amino>-2-oxo-1-pyrrolidineacetate

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; for 48h;
DOI:10.1021/jm00048a003

Reference yield:

: 16881-39-3
(S)-2-tert-butyl-1-benzylpyrrolidine-1,2-dicarboxylate

: 158268-46-3
methyl 3(R)-<<<1-<(benzyloxy)acetyl>-2(S)-pyrrolidinyl>carbonyl>amino>-2-oxo-1-pyrrolidineacetate

Guidance literature:: Multi-step reaction with 4 steps

1: H₂ / 10percent Pd/C / methanol / 1 h / 2068.6 Torr

2: Et₃N / CH₂Cl₂ / a) -20 deg C, 1 h, b) RT, 1 h

3: 100 percent / CF₃COOH / CH₂Cl₂ / 2 h

4: 77 percent / hydroxybenzotriazole, Et₃N, 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride / CH₂Cl₂ / 48 h

With hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; palladium on activated charcoal; In methanol; dichloromethane;
DOI:10.1021/jm00048a003

Reference yield:

: 2812-46-6
proline tert-butyl ester

: 158268-46-3
methyl 3(R)-<<<1-<(benzyloxy)acetyl>-2(S)-pyrrolidinyl>carbonyl>amino>-2-oxo-1-pyrrolidineacetate

Guidance literature:: Multi-step reaction with 3 steps

1: Et₃N / CH₂Cl₂ / a) -20 deg C, 1 h, b) RT, 1 h

2: 100 percent / CF₃COOH / CH₂Cl₂ / 2 h

3: 77 percent / hydroxybenzotriazole, Et₃N, 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride / CH₂Cl₂ / 48 h

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; In dichloromethane;
DOI:10.1021/jm00048a003