1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)-3-(4-((2-((3-ethynyl-5-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)phenyl)amino)pyrimidin-4-yl)oxy)naphthalen-1-yl)urea

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Chemical Name:1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)-3-(4-((2-((3-ethynyl-5-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)phenyl)amino)pyrimidin-4-yl)oxy)naphthalen-1-yl)urea
CAS No.:1610449-80-3
Molecular Formula:C₄₄H₄₇N₇O₆
Molecular Weight:769.9
Hs Code.:

1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)-3-(4-((2-((3-ethynyl-5-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)phenyl)amino)pyrimidin-4-yl)oxy)naphthalen-1-yl)urea

Synonyms:1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)-3-(4-((2-((3-ethynyl-5-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)phenyl)amino)pyrimidin-4-yl)oxy)naphthalen-1-yl)urea

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Chemical Property of 1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)-3-(4-((2-((3-ethynyl-5-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)phenyl)amino)pyrimidin-4-yl)oxy)naphthalen-1-yl)urea

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Technology Process of 1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)-3-(4-((2-((3-ethynyl-5-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)phenyl)amino)pyrimidin-4-yl)oxy)naphthalen-1-yl)urea

There total 8 articles about 1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)-3-(4-((2-((3-ethynyl-5-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)phenyl)amino)pyrimidin-4-yl)oxy)naphthalen-1-yl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 72593-77-2,92450-98-1
3,6,9-trioxadecyl bromide

: 1610449-80-3
1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)-3-(4-((2-((3-ethynyl-5-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)phenyl)amino)pyrimidin-4-yl)oxy)naphthalen-1-yl)urea

Guidance literature:: Multi-step reaction with 5 steps

1: sodium iodide; potassium carbonate / acetone / 16 h / Reflux

2: triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) iodide / N,N-dimethyl-formamide / 1 h / 85 °C

3: tetrabutyl ammonium fluoride / tetrahydrofuran; ethyl acetate / 1 h

4: iron; ammonium chloride / ethanol; water / 4 h / 65 °C / Sonication

5: toluene-4-sulfonic acid / N,N-dimethyl-formamide / 7 h / 70 °C

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetrabutyl ammonium fluoride; iron; potassium carbonate; ammonium chloride; toluene-4-sulfonic acid; triethylamine; sodium iodide; In tetrahydrofuran; ethanol; water; ethyl acetate; N,N-dimethyl-formamide; acetone;

Reference yield:

: 1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)-3-(4-((2-chloropyrimidin-4-yl)oxy)naphthalen-1-yl)urea

: 1610450-56-0
3-ethynyl-5-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)aniline

: 1610449-80-3
1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)-3-(4-((2-((3-ethynyl-5-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)phenyl)amino)pyrimidin-4-yl)oxy)naphthalen-1-yl)urea

Guidance literature:: With toluene-4-sulfonic acid; In N,N-dimethyl-formamide; at 70 ℃; for 7h;

Reference yield:

: 285984-47-6
[5-tert-butyl-2-(4-methylphenyl)-2H-pyrazol-3-yl]carbamic acid phenyl ester

: 1610449-80-3
1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)-3-(4-((2-((3-ethynyl-5-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)phenyl)amino)pyrimidin-4-yl)oxy)naphthalen-1-yl)urea

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / Isopropyl acetate / 1 h / 60 °C

2: toluene-4-sulfonic acid / N,N-dimethyl-formamide / 7 h / 70 °C

With toluene-4-sulfonic acid; triethylamine; In Isopropyl acetate; N,N-dimethyl-formamide;