(S)-2-({2-[3-(3-hydroxy-phenyl)propylamino]-4,6-dimethyl-pyrimidine-5-carbonyl}amino)-3-[(thiophene-2-carbonyl)amino]propionic acid 3-morpholin-4-yl-propyl ester

Base Information

Chemical Name:(S)-2-({2-[3-(3-hydroxy-phenyl)propylamino]-4,6-dimethyl-pyrimidine-5-carbonyl}amino)-3-[(thiophene-2-carbonyl)amino]propionic acid 3-morpholin-4-yl-propyl ester
CAS No.:1400705-00-1
Molecular Formula:C₃₁H₄₀N₆O₆S
Molecular Weight:624.761
Hs Code.:

(S)-2-({2-[3-(3-hydroxy-phenyl)propylamino]-4,6-dimethyl-pyrimidine-5-carbonyl}amino)-3-[(thiophene-2-carbonyl)amino]propionic acid 3-morpholin-4-yl-propyl ester

Synonyms:(S)-2-({2-[3-(3-hydroxy-phenyl)propylamino]-4,6-dimethyl-pyrimidine-5-carbonyl}amino)-3-[(thiophene-2-carbonyl)amino]propionic acid 3-morpholin-4-yl-propyl ester

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Chemical Property of (S)-2-({2-[3-(3-hydroxy-phenyl)propylamino]-4,6-dimethyl-pyrimidine-5-carbonyl}amino)-3-[(thiophene-2-carbonyl)amino]propionic acid 3-morpholin-4-yl-propyl ester

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Technology Process of (S)-2-({2-[3-(3-hydroxy-phenyl)propylamino]-4,6-dimethyl-pyrimidine-5-carbonyl}amino)-3-[(thiophene-2-carbonyl)amino]propionic acid 3-morpholin-4-yl-propyl ester

There total 3 articles about (S)-2-({2-[3-(3-hydroxy-phenyl)propylamino]-4,6-dimethyl-pyrimidine-5-carbonyl}amino)-3-[(thiophene-2-carbonyl)amino]propionic acid 3-morpholin-4-yl-propyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 7357-67-7
4-(3-chloropropyl)morpholine

: 1400703-89-0
(S)-2-({2-[3-(3-hydroxy-phenyl)propylamino]-4,6-dimethyl-pyrimidine-5-carbonyl}amino)-3-[(thiophene-2-carbonyl)amino]propionic acid methyl ester

: 1400705-00-1
(S)-2-({2-[3-(3-hydroxy-phenyl)propylamino]-4,6-dimethyl-pyrimidine-5-carbonyl}amino)-3-[(thiophene-2-carbonyl)amino]propionic acid 3-morpholin-4-yl-propyl ester

Guidance literature:: With triethylamine; sodium iodide; In N,N-dimethyl-formamide; at 120 ℃; for 0.333333h; microwave irradiation;

Reference yield:

: 1400703-88-9
(S)-2-({2-[3-(3-hydroxy-phenyl)propylamino]-4,6-dimethyl-pyrimidine-5-carbonyl}amino)-3-[(thiophene-2-carbonyl)amino]propionic acid methyl ester

: 1400705-00-1
(S)-2-({2-[3-(3-hydroxy-phenyl)propylamino]-4,6-dimethyl-pyrimidine-5-carbonyl}amino)-3-[(thiophene-2-carbonyl)amino]propionic acid 3-morpholin-4-yl-propyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: water; lithium hydroxide monohydrate / tetrahydrofuran / 1.5 h / 20 °C

2: triethylamine; sodium iodide / N,N-dimethyl-formamide / 0.33 h / 120 °C / microwave irradiation

With lithium hydroxide monohydrate; water; triethylamine; sodium iodide; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 1400863-17-3
(S)-3-amino-2-({2-[3-(3-hydroxy-phenyl)propoxy]-4,6-dimethyl-pyrimidine-5-carbonyl}amino)propionic acid methyl ester

: 1400705-00-1
(S)-2-({2-[3-(3-hydroxy-phenyl)propylamino]-4,6-dimethyl-pyrimidine-5-carbonyl}amino)-3-[(thiophene-2-carbonyl)amino]propionic acid 3-morpholin-4-yl-propyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 1 h / 20 °C

2: water; lithium hydroxide monohydrate / tetrahydrofuran / 1.5 h / 20 °C

3: triethylamine; sodium iodide / N,N-dimethyl-formamide / 0.33 h / 120 °C / microwave irradiation

With lithium hydroxide monohydrate; water; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; sodium iodide; In tetrahydrofuran; N,N-dimethyl-formamide;