Technology Process of 1-[1-(3-diethylaminopropyl)-1H-indol-3-yl]-3-(6-phenylpyrazin-2-yl)urea
There total 10 articles about 1-[1-(3-diethylaminopropyl)-1H-indol-3-yl]-3-(6-phenylpyrazin-2-yl)urea which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: sodium hydroxide / methanol; water / 36 h / 60 °C
2: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 5 h / 20 °C / Inert atmosphere
3: sodium azide / tetrahydrofuran; water / 4 h / 0 °C
4: toluene / 0.75 h / 100 °C / Sealed tube
5: toluene / 2 h / 100 °C / Sealed tube
With
sodium azide; oxalyl dichloride; N,N-dimethyl-formamide; sodium hydroxide;
In
tetrahydrofuran; methanol; dichloromethane; water; toluene;
4: Curtius rearrangement;
DOI:10.1016/j.bmc.2011.02.036
- Guidance literature:
-
Multi-step reaction with 8 steps
1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 20 °C
2: 2,6-dimethylpyridine / dichloromethane / 5 h / 0 °C / Inert atmosphere
3: tetrahydrofuran; dichloromethane / 16 h / 0 - 20 °C / Inert atmosphere
4: sodium hydroxide / methanol; water / 36 h / 60 °C
5: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 5 h / 20 °C / Inert atmosphere
6: sodium azide / tetrahydrofuran; water / 4 h / 0 °C
7: toluene / 0.75 h / 100 °C / Sealed tube
8: toluene / 2 h / 100 °C / Sealed tube
With
2,6-dimethylpyridine; sodium azide; oxalyl dichloride; tetrabutyl ammonium fluoride; N,N-dimethyl-formamide; sodium hydroxide;
In
tetrahydrofuran; methanol; dichloromethane; water; toluene;
7: Curtius rearrangement;
DOI:10.1016/j.bmc.2011.02.036
