(+)-N₁,N₄-di-(tert-butyloxycarbonyl)-N-[3-[(5-methyl-1H-imidazol-1-yl)methyl]phenyl]-(2R)-piperazinecarboxamide

Base Information

• Chemical Name: (+)-N₁,N₄-di-(tert-butyloxycarbonyl)-N-[3-[(5-methyl-1H-imidazol-1-yl)methyl]phenyl]-(2R)-piperazinecarboxamide
• CAS No.: 892393-46-3
• Molecular Formula: C₂₆H₃₇N₅O₅
• Molecular Weight: 499.61

Synonyms:(+)-N₁,N₄-di-(tert-butyloxycarbonyl)-N-[3-[(5-methyl-1H-imidazol-1-yl)methyl]phenyl]-(2R)-piperazinecarboxamide

Chemical Property of (+)-N₁,N₄-di-(tert-butyloxycarbonyl)-N-[3-[(5-methyl-1H-imidazol-1-yl)methyl]phenyl]-(2R)-piperazinecarboxamide

Chemical Property:

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Technology Process of (+)-N₁,N₄-di-(tert-butyloxycarbonyl)-N-[3-[(5-methyl-1H-imidazol-1-yl)methyl]phenyl]-(2R)-piperazinecarboxamide

There total 1 articles about (+)-N₁,N₄-di-(tert-butyloxycarbonyl)-N-[3-[(5-methyl-1H-imidazol-1-yl)methyl]phenyl]-(2R)-piperazinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

(R)-piperazine-1,2,4-tricarboxylic acid 1,4-di-tert-butyl ester (173774-48-6) + 1-(3-aminophenyl)-1-(5-methyl-1H-imidazol-1-yl)methane (892393-26-9) → (+)-N1,N4-di-(tert-butyloxycarbonyl)-N-[3-[(5-methyl-1H-imidazol-1-yl)methyl]phenyl]-(2R)-piperazinecarboxamide (892393-46-3)

Guidance literature:

With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 25 ℃; for 330h;

upstream raw materials:

(R)-piperazine-1,2,4-tricarboxylic acid 1,4-di-tert-butyl ester

1-(3-aminophenyl)-1-(5-methyl-1H-imidazol-1-yl)methane

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