6-Phenyl-4-(trifluoromethyl)pyridin-2(1H)-one

Base Information

Chemical Name:6-Phenyl-4-(trifluoromethyl)pyridin-2(1H)-one
CAS No.:22122-89-0
Molecular Formula:C12H8 F3 N O
Molecular Weight:239.197
Hs Code.:2933399090
DSSTox Substance ID:DTXSID10571534
Wikidata:Q82459632
Mol file:22122-89-0.mol

Synonyms:22122-89-0;6-Phenyl-4-(trifluoromethyl)pyridin-2(1H)-one;6-phenyl-4-(trifluoromethyl)-1H-pyridin-2-one;2-Hydroxy-6-phenyl-4-(trifluoromethyl)pyridine;DTXSID10571534;WBOFHZOUVBKGQK-UHFFFAOYSA-N

Suppliers and Price of 6-Phenyl-4-(trifluoromethyl)pyridin-2(1H)-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
4-(TRIFLUOROMETHYL)-6-PHENYLPYRIDIN-2(1H)-ONE 95.00%
1G
$ 1030.84

American Custom Chemicals Corporation
4-(TRIFLUOROMETHYL)-6-PHENYLPYRIDIN-2(1H)-ONE 95.00%
500MG
$ 817.62

American Custom Chemicals Corporation
4-(TRIFLUOROMETHYL)-6-PHENYLPYRIDIN-2(1H)-ONE 95.00%
10G
$ 7882.88

American Custom Chemicals Corporation
4-(TRIFLUOROMETHYL)-6-PHENYLPYRIDIN-2(1H)-ONE 95.00%
5G
$ 4244.63

Alichem
2-Hydroxy-6-phenyl-4-(trifluoromethyl)pyridine
1g
$ 3068.70

Alichem
2-Hydroxy-6-phenyl-4-(trifluoromethyl)pyridine
500mg
$ 1600.75

Total 5 raw suppliers

Chemical Property of 6-Phenyl-4-(trifluoromethyl)pyridin-2(1H)-one

Chemical Property:

PSA：32.86000
LogP:3.06070
XLogP3:2.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:239.05579836
Heavy Atom Count:17
Complexity:376

Purity/Quality:

99% ^*data from raw suppliers

4-(TRIFLUOROMETHYL)-6-PHENYLPYRIDIN-2(1H)-ONE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C(C=C1)C2=CC(=CC(=O)N2)C(F)(F)F

Technology Process of 6-Phenyl-4-(trifluoromethyl)pyridin-2(1H)-one

There total 12 articles about 6-Phenyl-4-(trifluoromethyl)pyridin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 25597-16-4,91600-34-9,406-10-0
ethyl 4,4,4-trifluorobut-2-enoate

: 19433-17-1
acetophenone O-acetyloxime

: 22122-89-0
1,2-Dihydro-2-oxo-6-phenyl-4-trifluoromethylpyridine

Guidance literature:: With sodium acetate; copper(l) chloride; In dimethyl sulfoxide; at 100 ℃; for 24h; Temperature; regioselective reaction; Catalytic behavior; Inert atmosphere; Schlenk technique; Sealed tube;
DOI:10.1002/anie.201802311

Reference yield: 89.0%

: 6-phenyl-4-(trifluoromethyl)pyridin-2-yl 4-methylbenzene-1-sulfonate

: 22122-89-0
1,2-Dihydro-2-oxo-6-phenyl-4-trifluoromethylpyridine

Guidance literature:: With tetra(n-butyl)ammonium hydroxide; In ethanol; water; at 20 ℃; for 0.25h;
DOI:10.1002/anie.201306786

Reference yield: 47.0%

: 49639-34-1,90617-28-0
phenylsulfinylacetic acid amide

: 114192-88-0,136964-14-2,3108-34-7
(E)-4,4,4-trifluoro-1-phenylbut-2-en-1-one

: 22122-89-0
1,2-Dihydro-2-oxo-6-phenyl-4-trifluoromethylpyridine

Guidance literature:: phenylsulfinylacetic acid amide; (E)-4,4,4-trifluoro-1-phenylbut-2-en-1-one; With 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride; In acetonitrile; at 20 ℃; for 4h;

With acetic acid; In acetonitrile; at 82 ℃; for 10h;
DOI:10.1055/s-0037-1612077