toluene-4-sulfonic acid 2-(5-tert-butoxycarbonylamino-2,2-dimethyl-[1,3]dioxan-4-yl)-propyl ester

Base Information

Chemical Name:toluene-4-sulfonic acid 2-(5-tert-butoxycarbonylamino-2,2-dimethyl-[1,3]dioxan-4-yl)-propyl ester
CAS No.:872997-46-1
Molecular Formula:C₂₁H₃₃NO₇S
Molecular Weight:443.562
Hs Code.:

toluene-4-sulfonic acid 2-(5-<i>tert</i>-butoxycarbonylamino-2,2-dimethyl-[1,3]dioxan-4-yl)-propyl ester

Synonyms:toluene-4-sulfonic acid 2-(5-tert-butoxycarbonylamino-2,2-dimethyl-[1,3]dioxan-4-yl)-propyl ester

Suppliers and Price of toluene-4-sulfonic acid 2-(5-tert-butoxycarbonylamino-2,2-dimethyl-[1,3]dioxan-4-yl)-propyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of toluene-4-sulfonic acid 2-(5-tert-butoxycarbonylamino-2,2-dimethyl-[1,3]dioxan-4-yl)-propyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of toluene-4-sulfonic acid 2-(5-tert-butoxycarbonylamino-2,2-dimethyl-[1,3]dioxan-4-yl)-propyl ester

There total 5 articles about toluene-4-sulfonic acid 2-(5-tert-butoxycarbonylamino-2,2-dimethyl-[1,3]dioxan-4-yl)-propyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 872997-45-0
[4-(2-hydroxy-1-methyl-ethyl)-2,2-dimethyl-[1,3]dioxan-5-yl]-carbamic acid tert-butyl ester

: 98-59-9
p-toluenesulfonyl chloride

: 872997-46-1
toluene-4-sulfonic acid 2-(5-tert-butoxycarbonylamino-2,2-dimethyl-[1,3]dioxan-4-yl)-propyl ester

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 20 ℃; for 2.5h;
DOI:10.3987/COM-05-10500

Reference yield:

: 102308-32-7
(4S)-4-formyl-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

: 872997-46-1
toluene-4-sulfonic acid 2-(5-tert-butoxycarbonylamino-2,2-dimethyl-[1,3]dioxan-4-yl)-propyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: 66 percent / CrCl₂ / tetrahydrofuran / 2.5 h / 20 °C

2.1: 75 percent / p-TsOH*H₂O / methanol / 2 h / 20 °C

3.1: 53 percent / p-TsOH*H₂O / 2 h / 20 °C

4.1: O₃ / methanol / 3 h / -78 °C

4.2: 97 percent / NaBH₄ / methanol / -78 - 20 °C

5.1: 98 percent / Et₃N; DMAP / CH₂Cl₂ / 2.5 h / 20 °C

With chromium dichloride; dmap; toluene-4-sulfonic acid; ozone; triethylamine; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.3987/COM-05-10500

Reference yield:

: 140630-93-9
(S)-4-((1R,2R)-1-Hydroxy-2-methyl-but-3-enyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

: 872997-46-1
toluene-4-sulfonic acid 2-(5-tert-butoxycarbonylamino-2,2-dimethyl-[1,3]dioxan-4-yl)-propyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: 75 percent / p-TsOH*H₂O / methanol / 2 h / 20 °C

2.1: 53 percent / p-TsOH*H₂O / 2 h / 20 °C

3.1: O₃ / methanol / 3 h / -78 °C

3.2: 97 percent / NaBH₄ / methanol / -78 - 20 °C

4.1: 98 percent / Et₃N; DMAP / CH₂Cl₂ / 2.5 h / 20 °C

With dmap; toluene-4-sulfonic acid; ozone; triethylamine; In methanol; dichloromethane;
DOI:10.3987/COM-05-10500