(2,2-dimethyl-piperazin-1-yl)-(1-phenyl-1-H-[1,2,4]-triazol-3-yl)-methanone trifluoroacetate

Base Information

Chemical Name:(2,2-dimethyl-piperazin-1-yl)-(1-phenyl-1-H-[1,2,4]-triazol-3-yl)-methanone trifluoroacetate
CAS No.:1443759-20-3
Molecular Formula:C₂HF₃O₂*C₁₅H₁₉N₅O
Molecular Weight:399.373
Hs Code.:

Synonyms:(2,2-dimethyl-piperazin-1-yl)-(1-phenyl-1-H-[1,2,4]-triazol-3-yl)-methanone trifluoroacetate

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Chemical Property of (2,2-dimethyl-piperazin-1-yl)-(1-phenyl-1-H-[1,2,4]-triazol-3-yl)-methanone trifluoroacetate

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Technology Process of (2,2-dimethyl-piperazin-1-yl)-(1-phenyl-1-H-[1,2,4]-triazol-3-yl)-methanone trifluoroacetate

There total 4 articles about (2,2-dimethyl-piperazin-1-yl)-(1-phenyl-1-H-[1,2,4]-triazol-3-yl)-methanone trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1443759-18-9
3,3-dimethyl-4-(1-phenyl-1Η-[1,2,4]triazole-3-carbonyl)-piperazine-1-carboxylic acid tert-butyl ester

: 76-05-1
trifluoroacetic acid

: 1443759-20-3
(2,2-dimethyl-piperazin-1-yl)-(1-phenyl-1-H-[1,2,4]-triazol-3-yl)-methanone trifluoroacetate

Guidance literature:: In dichloromethane; at 20 ℃; for 4h;

Reference yield:

: 62-53-3
aniline

: 1443759-20-3
(2,2-dimethyl-piperazin-1-yl)-(1-phenyl-1-H-[1,2,4]-triazol-3-yl)-methanone trifluoroacetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium nitrite; tetrafluoroboric acid / water / 1 h / 0 °C

1.2: 20 °C / Cooling with ice

1.3: 48 h

2.1: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 2 h / 20 °C

3.1: dichloromethane / 4 h / 20 °C

With tetrafluoroboric acid; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; sodium nitrite; In dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 98-80-6
phenylboronic acid

: 1443759-20-3
(2,2-dimethyl-piperazin-1-yl)-(1-phenyl-1-H-[1,2,4]-triazol-3-yl)-methanone trifluoroacetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyridine; copper diacetate / dichloromethane / 72 h / 20 °C

1.2: 20 °C

2.1: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 2 h / 20 °C

3.1: dichloromethane / 4 h / 20 °C

With pyridine; copper diacetate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide;