Technology Process of (1S,3R,5R,8aR)-3-isopropenyl-5,8a-dimethyl-1,2,3,5,8,8a-hexahydro-1-naphthalenyl benzoate
There total 8 articles about (1S,3R,5R,8aR)-3-isopropenyl-5,8a-dimethyl-1,2,3,5,8,8a-hexahydro-1-naphthalenyl benzoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
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615577-68-9
(1S,3R,4aR,5R,8aS)-4a-hydroxy-3-isopropenyl-5,8a-dimethyl-1,2,3,4,4a,5,8,8a-octahydro-1-naphthalenyl benzoate
- Guidance literature:
-
With
thionyl chloride;
In
pyridine;
at -35 ℃;
DOI:10.1016/S0040-4039(03)01757-X
- Guidance literature:
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Multi-step reaction with 7 steps
1: Li; NH3 / diethyl ether / -78 °C
2: CeCl3 / tetrahydrofuran / -78 °C
3: 95 percent / [benzylidene-bis(tricyclohexylphosphine)-dichlororuthenium] / benzene / 85 °C
4: 78 percent / PCC / CH2Cl2 / 20 °C
5: NaBH4 / methanol / 0 °C
6: 87 percent / Et3N; DMAP / CH2Cl2 / 20 °C
7: 80 percent / SOCl2 / pyridine / -35 °C
With
Grubbs catalyst first generation; dmap; sodium tetrahydroborate; thionyl chloride; cerium(III) chloride; ammonia; lithium; triethylamine; pyridinium chlorochromate;
In
tetrahydrofuran; pyridine; methanol; diethyl ether; dichloromethane; benzene;
DOI:10.1016/S0040-4039(03)01757-X
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 92 percent / H2O2; NaOH; water / methanol / 0 °C
2: Li; NH3 / diethyl ether / -78 °C
3: CeCl3 / tetrahydrofuran / -78 °C
4: 95 percent / [benzylidene-bis(tricyclohexylphosphine)-dichlororuthenium] / benzene / 85 °C
5: 78 percent / PCC / CH2Cl2 / 20 °C
6: NaBH4 / methanol / 0 °C
7: 87 percent / Et3N; DMAP / CH2Cl2 / 20 °C
8: 80 percent / SOCl2 / pyridine / -35 °C
With
Grubbs catalyst first generation; dmap; sodium hydroxide; sodium tetrahydroborate; thionyl chloride; cerium(III) chloride; ammonia; water; dihydrogen peroxide; lithium; triethylamine; pyridinium chlorochromate;
In
tetrahydrofuran; pyridine; methanol; diethyl ether; dichloromethane; benzene;
DOI:10.1016/S0040-4039(03)01757-X
