(R)-4-(4-(hydroxyamino)-4-oxobutyl)phenyl-3-(5-(benzyloxy)pyridin-2-yl)-2-(tert-butoxycarbonylamino)propanoate

Base Information

Chemical Name:(R)-4-(4-(hydroxyamino)-4-oxobutyl)phenyl-3-(5-(benzyloxy)pyridin-2-yl)-2-(tert-butoxycarbonylamino)propanoate
CAS No.:1350618-52-8
Molecular Formula:C₃₀H₃₅N₃O₇
Molecular Weight:549.624
Hs Code.:

Synonyms:(R)-4-(4-(hydroxyamino)-4-oxobutyl)phenyl-3-(5-(benzyloxy)pyridin-2-yl)-2-(tert-butoxycarbonylamino)propanoate

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Chemical Property of (R)-4-(4-(hydroxyamino)-4-oxobutyl)phenyl-3-(5-(benzyloxy)pyridin-2-yl)-2-(tert-butoxycarbonylamino)propanoate

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Technology Process of (R)-4-(4-(hydroxyamino)-4-oxobutyl)phenyl-3-(5-(benzyloxy)pyridin-2-yl)-2-(tert-butoxycarbonylamino)propanoate

There total 4 articles about (R)-4-(4-(hydroxyamino)-4-oxobutyl)phenyl-3-(5-(benzyloxy)pyridin-2-yl)-2-(tert-butoxycarbonylamino)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1350618-59-5
(2R)-4-(4-oxo-4-(tetrahydro-2H-pyran-2-yloxyamino)butyl)phenyl 3-(5-(benzyloxy)pyridin-2-yl)-2-(tert-butoxycarbonylamino)propanoate

: 1350618-52-8
(R)-4-(4-(hydroxyamino)-4-oxobutyl)phenyl-3-(5-(benzyloxy)pyridin-2-yl)-2-(tert-butoxycarbonylamino)propanoate

Guidance literature:: With Dowex 50wX₈; for 1h; Reflux;

Reference yield:

: 7021-11-6
4-(4-hydroxyphenyl)butanoic acid

: 1350618-52-8
(R)-4-(4-(hydroxyamino)-4-oxobutyl)phenyl-3-(5-(benzyloxy)pyridin-2-yl)-2-(tert-butoxycarbonylamino)propanoate

Guidance literature:: Multi-step reaction with 3 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 2 h / 20 °C

2: dmap; dicyclohexyl-carbodiimide / dichloromethane / 1 h / 0 - 20 °C

3: Dowex 50wX₈ / 1 h / Reflux

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dicyclohexyl-carbodiimide; In dichloromethane;

Reference yield:

: 4521-28-2
4-(4-Methoxyphenyl)butyric acid

: 1350618-52-8
(R)-4-(4-(hydroxyamino)-4-oxobutyl)phenyl-3-(5-(benzyloxy)pyridin-2-yl)-2-(tert-butoxycarbonylamino)propanoate

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogen bromide; acetic acid / 12 h / Reflux

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 2 h / 20 °C

3: dmap; dicyclohexyl-carbodiimide / dichloromethane / 1 h / 0 - 20 °C

4: Dowex 50wX₈ / 1 h / Reflux

With dmap; hydrogen bromide; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dicyclohexyl-carbodiimide; In dichloromethane;