N-[3-(cyclopropyl{5,6,7,8,9,10-hexahydro-4-[(phenylsulfonyl)oxy]-2-oxo-2H-cycloocta[b]pyran-3-yl}methyl)phenyl]-N-(phenylsulfonyl)benzenesulfonamide

Base Information

• Chemical Name: N-[3-(cyclopropyl{5,6,7,8,9,10-hexahydro-4-[(phenylsulfonyl)oxy]-2-oxo-2H-cycloocta[b]pyran-3-yl}methyl)phenyl]-N-(phenylsulfonyl)benzenesulfonamide
• CAS No.: 188308-30-7
• Molecular Formula: C₃₉H₃₇NO₉S₃
• Molecular Weight: 759.922

Synonyms:N-[3-(cyclopropyl{5,6,7,8,9,10-hexahydro-4-[(phenylsulfonyl)oxy]-2-oxo-2H-cycloocta[b]pyran-3-yl}methyl)phenyl]-N-(phenylsulfonyl)benzenesulfonamide

Chemical Property of N-[3-(cyclopropyl{5,6,7,8,9,10-hexahydro-4-[(phenylsulfonyl)oxy]-2-oxo-2H-cycloocta[b]pyran-3-yl}methyl)phenyl]-N-(phenylsulfonyl)benzenesulfonamide

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Technology Process of N-[3-(cyclopropyl{5,6,7,8,9,10-hexahydro-4-[(phenylsulfonyl)oxy]-2-oxo-2H-cycloocta[b]pyran-3-yl}methyl)phenyl]-N-(phenylsulfonyl)benzenesulfonamide

There total 5 articles about N-[3-(cyclopropyl{5,6,7,8,9,10-hexahydro-4-[(phenylsulfonyl)oxy]-2-oxo-2H-cycloocta[b]pyran-3-yl}methyl)phenyl]-N-(phenylsulfonyl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5,6,7,8,9,10-Hexahydro-4-hydroxy-2H-cyclooctapyran-2-on (100058-82-0) → N-[3-(cyclopropyl{5,6,7,8,9,10-hexahydro-4-[(phenylsulfonyl)oxy]-2-oxo-2H-cycloocta[b]pyran-3-yl}methyl)phenyl]-N-(phenylsulfonyl)benzenesulfonamide (188308-30-7)

Guidance literature:

Multi-step reaction with 4 steps

1: p-toluenesulfonic acid / toluene / 72 h / 20 °C

2: H₂ / 10percent Pd/C / methanol / 18 h / 2482.3 Torr

3: 39 percent / pyridine / 1,2-dichloro-ethane / 16 h / Ambient temperature

4: 1.) n-BuLi / 1.) THF, -78 deg C, 30 min, 2.) THF, reflux, 3.5 h

With pyridine; n-butyllithium; hydrogen; toluene-4-sulfonic acid; palladium on activated charcoal; In methanol; 1,2-dichloro-ethane; toluene;

DOI:10.1021/jm960441m

Reference yield:

m-<(benzyloxycarbonyl)amino>phenyl cyclopropyl carbinol (162174-77-8) → N-[3-(cyclopropyl{5,6,7,8,9,10-hexahydro-4-[(phenylsulfonyl)oxy]-2-oxo-2H-cycloocta[b]pyran-3-yl}methyl)phenyl]-N-(phenylsulfonyl)benzenesulfonamide (188308-30-7)

Guidance literature:

Multi-step reaction with 4 steps

1: p-toluenesulfonic acid / toluene / 72 h / 20 °C

2: H₂ / 10percent Pd/C / methanol / 18 h / 2482.3 Torr

3: 39 percent / pyridine / 1,2-dichloro-ethane / 16 h / Ambient temperature

4: 1.) n-BuLi / 1.) THF, -78 deg C, 30 min, 2.) THF, reflux, 3.5 h

With pyridine; n-butyllithium; hydrogen; toluene-4-sulfonic acid; palladium on activated charcoal; In methanol; 1,2-dichloro-ethane; toluene;

DOI:10.1021/jm960441m

Reference yield:

<3-pyran-3-yl)methyl>phenyl>carbamic acid, phenylmethyl ester (166282-28-6,166335-05-3) → N-[3-(cyclopropyl{5,6,7,8,9,10-hexahydro-4-[(phenylsulfonyl)oxy]-2-oxo-2H-cycloocta[b]pyran-3-yl}methyl)phenyl]-N-(phenylsulfonyl)benzenesulfonamide (188308-30-7)

Guidance literature:

Multi-step reaction with 3 steps

1: H₂ / 10percent Pd/C / methanol / 18 h / 2482.3 Torr

2: 39 percent / pyridine / 1,2-dichloro-ethane / 16 h / Ambient temperature

3: 1.) n-BuLi / 1.) THF, -78 deg C, 30 min, 2.) THF, reflux, 3.5 h

With pyridine; n-butyllithium; hydrogen; palladium on activated charcoal; In methanol; 1,2-dichloro-ethane;

DOI:10.1021/jm960441m

upstream raw materials:

benzenesulfonyl chloride

5,6,7,8,9,10-Hexahydro-4-hydroxy-2H-cyclooctapyran-2-on

m-<(benzyloxycarbonyl)amino>phenyl cyclopropyl carbinol

3-<(3-aminophenyl)cyclopropylmethyl>-5,6,7,8,9,10-hexahydro-4-hydroxy-2H-cyclooctapyran-2-one

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