tert-butyl 2-(8-(benzyloxy)-1,2,3,4-tetrahydropyrazino[1,2-a]indol-1-yl)acetate

Base Information

Chemical Name:tert-butyl 2-(8-(benzyloxy)-1,2,3,4-tetrahydropyrazino[1,2-a]indol-1-yl)acetate
CAS No.:1262008-60-5
Molecular Formula:C₂₄H₂₈N₂O₃
Molecular Weight:392.498
Hs Code.:

Synonyms:tert-butyl 2-(8-(benzyloxy)-1,2,3,4-tetrahydropyrazino[1,2-a]indol-1-yl)acetate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of tert-butyl 2-(8-(benzyloxy)-1,2,3,4-tetrahydropyrazino[1,2-a]indol-1-yl)acetate

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Technology Process of tert-butyl 2-(8-(benzyloxy)-1,2,3,4-tetrahydropyrazino[1,2-a]indol-1-yl)acetate

There total 6 articles about tert-butyl 2-(8-(benzyloxy)-1,2,3,4-tetrahydropyrazino[1,2-a]indol-1-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: tert-butyl 3-(5-(benzyloxy)-1-(2-(methylsulfonyloxy)ethyI)-1H-indol-2-yl)acrylate

: 1262008-60-5
tert-butyl 2-(8-(benzyloxy)-1,2,3,4-tetrahydropyrazino[1,2-a]indol-1-yl)acetate

Guidance literature:: With ammonia; In 1,4-dioxane; methanol; at 100 ℃;
DOI:10.1016/j.bmcl.2014.11.089

Reference yield:

: tert-butyl 3-(5-(benzyloxy)-1H-indol-2-yl)acrylate

: 1262008-60-5
tert-butyl 2-(8-(benzyloxy)-1,2,3,4-tetrahydropyrazino[1,2-a]indol-1-yl)acetate

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 - 80 °C / sealed tube

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 3 h / 20 °C

3: dmap / dichloromethane / 0.5 h / 0 °C

4: ammonia / 1,4-dioxane; methanol / 18 h / 80 °C / sealed tube

With dmap; tetrabutyl ammonium fluoride; ammonia; sodium hydride; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: tert-butyl 3-(5-(benzyloxy)-1-(2-(tert-butyldimethylsilyloxy)ethyl)-1H-indol-2-yl)acrylate

: 1262008-60-5
tert-butyl 2-(8-(benzyloxy)-1,2,3,4-tetrahydropyrazino[1,2-a]indol-1-yl)acetate

Guidance literature:: Multi-step reaction with 3 steps

1: tetrabutyl ammonium fluoride / tetrahydrofuran / 3 h / 20 °C

2: dmap / dichloromethane / 0.5 h / 0 °C

3: ammonia / 1,4-dioxane; methanol / 18 h / 80 °C / sealed tube

With dmap; tetrabutyl ammonium fluoride; ammonia; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane;