2-ACETAMIDO-5-BROMOTOLUENE

Base Information

• Chemical Name: 2-ACETAMIDO-5-BROMOTOLUENE
• CAS No.: 22062-55-1
• Molecular Formula: C8H8ClF
• Molecular Weight: 158.6005
• Hs Code.: 2903999090
• Mol file: 22062-55-1.mol

Synonyms:5-Fluoro-2-methylbenzyl chloride;2-Methyl-5-fluorobenzyl chloride;

Chemical Property of 2-ACETAMIDO-5-BROMOTOLUENE

Chemical Property:

• Vapor Pressure: 0.488mmHg at 25°C
• Refractive Index: 1.505
• Boiling Point: 199.2 °C at 760 mmHg
• Flash Point: 76.3 °C
• PSA: 0.00000
• Density: 1.152 g/cm³
• LogP: 2.87290

Purity/Quality:

97% ^*data from raw suppliers

5-Fluoro-2-methylbenzyl chloride 99.0% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-ACETAMIDO-5-BROMOTOLUENE

There total 3 articles about 2-ACETAMIDO-5-BROMOTOLUENE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(5-fluoro-2-methylphenyl)methanol (22062-54-0) → 2-(chloromethyl)-4-fluoro-1-methylbenzene (22062-55-1)

Guidance literature:

With hydrogenchloride;

DOI:10.1021/ja01026a027

Reference yield:

4-fluoro-2-iodotoluene (13194-67-7) → 2-(chloromethyl)-4-fluoro-1-methylbenzene (22062-55-1)

Guidance literature:

Multi-step reaction with 3 steps

2: LiAlH₄

3: HCl

With hydrogenchloride; lithium aluminium tetrahydride;

DOI:10.1021/ja01026a027

Reference yield:

5-fluoro-2-methylbenzaldehyde (22062-53-9) → 2-(chloromethyl)-4-fluoro-1-methylbenzene (22062-55-1)

Guidance literature:

Multi-step reaction with 2 steps

1: LiAlH₄

2: HCl

With hydrogenchloride; lithium aluminium tetrahydride;

DOI:10.1021/ja01026a027

upstream raw materials:

(5-fluoro-2-methylphenyl)methanol

4-fluoro-2-iodotoluene

5-fluoro-2-methylbenzaldehyde

Downstream raw materials:

5-fluoro-2-methylbenzeneacetonitrile

2,2'-Dimethyl-5,5'-difluor-trans-stilben