(R)-3-[4-(4-fluoro-3-trifluoromethyl-phenyl)-2-piperidin-4-yl-imidazol-1-yl]-1-methyl-piperidine

Base Information

Chemical Name:(R)-3-[4-(4-fluoro-3-trifluoromethyl-phenyl)-2-piperidin-4-yl-imidazol-1-yl]-1-methyl-piperidine
CAS No.:1226804-50-7
Molecular Formula:C₂₁H₂₆F₄N₄
Molecular Weight:410.458
Hs Code.:

Synonyms:(R)-3-[4-(4-fluoro-3-trifluoromethyl-phenyl)-2-piperidin-4-yl-imidazol-1-yl]-1-methyl-piperidine

Suppliers and Price of (R)-3-[4-(4-fluoro-3-trifluoromethyl-phenyl)-2-piperidin-4-yl-imidazol-1-yl]-1-methyl-piperidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (R)-3-[4-(4-fluoro-3-trifluoromethyl-phenyl)-2-piperidin-4-yl-imidazol-1-yl]-1-methyl-piperidine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (R)-3-[4-(4-fluoro-3-trifluoromethyl-phenyl)-2-piperidin-4-yl-imidazol-1-yl]-1-methyl-piperidine

There total 1 articles about (R)-3-[4-(4-fluoro-3-trifluoromethyl-phenyl)-2-piperidin-4-yl-imidazol-1-yl]-1-methyl-piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1226804-48-3
4-[4-(4-fluoro-3-trifluoromethyl-phenyl)-1-((R)-1-methyl-piperidin-3-yl)-1H-imidazol-2-yl]-piperidine-1-carboxylic acid tert-butyl ester

: 1226804-50-7
(R)-3-[4-(4-fluoro-3-trifluoromethyl-phenyl)-2-piperidin-4-yl-imidazol-1-yl]-1-methyl-piperidine

Guidance literature:: 4-[4-(4-fluoro-3-trifluoromethyl-phenyl)-1-((R)-1-methyl-piperidin-3-yl)-1H-imidazol-2-yl]-piperidine-1-carboxylic acid tert-butyl ester; With hydrogenchloride; In 1,4-dioxane; methanol; dichloromethane; for 1h;

With sodium hydrogencarbonate; In dichloromethane; water;

Reference yield:

: 1226804-50-7
(R)-3-[4-(4-fluoro-3-trifluoromethyl-phenyl)-2-piperidin-4-yl-imidazol-1-yl]-1-methyl-piperidine

: 346599-63-1
4-chloro-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one

: 1226800-60-7
4-{4-[4-(4-Fluoro-3-trifluoromethyl-phenyl)-1-((R)-1-methyl-piperidin-3-yl)-1H-imidazol-2-yl]-piperidin-1-yl}-5,7-dihydro-pyrrolo[2,3-d]pyrimidin-6-one hydrochloride

Guidance literature:: (R)-3-[4-(4-fluoro-3-trifluoromethyl-phenyl)-2-piperidin-4-yl-imidazol-1-yl]-1-methyl-piperidine; 4-chloro-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one; With potassium tert-butylate; N,N'-bis(2,6-diisopropylphenyl)imidazol-2-ylidene-acetylacetonate palladium chloride; In 1,2-dimethoxyethane; at 80 ℃; for 18h; Inert atmosphere;

With hydrogenchloride; In diethyl ether; dichloromethane;