6-[2-(tert-butoxycarbonyl-{2-[5-(2,2,2-trichloro-ethoxycarbonyl)-pentylcarbamoyl]-ethyl}-amino)-acetylamino]-hexanoic acid benzyl ester

Base Information

Chemical Name:6-[2-(tert-butoxycarbonyl-{2-[5-(2,2,2-trichloro-ethoxycarbonyl)-pentylcarbamoyl]-ethyl}-amino)-acetylamino]-hexanoic acid benzyl ester
CAS No.:890649-85-1
Molecular Formula:C₃₁H₄₆Cl₃N₃O₈
Molecular Weight:695.081
Hs Code.:

6-[2-(<i>tert</i>-butoxycarbonyl-{2-[5-(2,2,2-trichloro-ethoxycarbonyl)-pentylcarbamoyl]-ethyl}-amino)-acetylamino]-hexanoic acid benzyl ester

Synonyms:6-[2-(tert-butoxycarbonyl-{2-[5-(2,2,2-trichloro-ethoxycarbonyl)-pentylcarbamoyl]-ethyl}-amino)-acetylamino]-hexanoic acid benzyl ester

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Chemical Property of 6-[2-(tert-butoxycarbonyl-{2-[5-(2,2,2-trichloro-ethoxycarbonyl)-pentylcarbamoyl]-ethyl}-amino)-acetylamino]-hexanoic acid benzyl ester

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Technology Process of 6-[2-(tert-butoxycarbonyl-{2-[5-(2,2,2-trichloro-ethoxycarbonyl)-pentylcarbamoyl]-ethyl}-amino)-acetylamino]-hexanoic acid benzyl ester

There total 3 articles about 6-[2-(tert-butoxycarbonyl-{2-[5-(2,2,2-trichloro-ethoxycarbonyl)-pentylcarbamoyl]-ethyl}-amino)-acetylamino]-hexanoic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 890649-84-0
6-{2-[tert-butoxycarbonyl-(2-carboxy-ethyl)-amino]-acetylamino}-hexanoic acid benzyl ester

: 2,2,2,-trichloroethyl 6-aminohexanoate tosylate

: 890649-85-1
6-[2-(tert-butoxycarbonyl-{2-[5-(2,2,2-trichloro-ethoxycarbonyl)-pentylcarbamoyl]-ethyl}-amino)-acetylamino]-hexanoic acid benzyl ester

Guidance literature:: With diethyl cyanophosphonate; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 16h;
DOI:10.1016/j.carres.2006.02.015

Reference yield:

: 890649-83-9
6-(2-{tert-butoxycarbonyl-[2-(2,2,2-trichloro-ethoxycarbonyl)-ethyl]-amino}-acetylamino)-hexanoic acid benzyl ester

: 890649-85-1
6-[2-(tert-butoxycarbonyl-{2-[5-(2,2,2-trichloro-ethoxycarbonyl)-pentylcarbamoyl]-ethyl}-amino)-acetylamino]-hexanoic acid benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 80 percent / AcOH; Zn

2: 64 percent / diethyl phosphorocyanidate; Et₃N / dimethylformamide / 16 h / 20 °C

With diethyl cyanophosphonate; acetic acid; triethylamine; zinc; In N,N-dimethyl-formamide;
DOI:10.1016/j.carres.2006.02.015

Reference yield:

: 649728-21-2
3-(tert-butoxycarbonyl-carboxymethylamino)-propionic acid 2,2,2-trichloroethylester

: 890649-85-1
6-[2-(tert-butoxycarbonyl-{2-[5-(2,2,2-trichloro-ethoxycarbonyl)-pentylcarbamoyl]-ethyl}-amino)-acetylamino]-hexanoic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 77 percent / diethyl phosphorocyanidate; Et₃N / dimethylformamide / 16 h / 20 °C

2: 80 percent / AcOH; Zn

3: 64 percent / diethyl phosphorocyanidate; Et₃N / dimethylformamide / 16 h / 20 °C

With diethyl cyanophosphonate; acetic acid; triethylamine; zinc; In N,N-dimethyl-formamide;
DOI:10.1016/j.carres.2006.02.015