7-[4-(2-butoxyethoxy)phenyl]-2,3-dihydro-1H-1-benzazepine-4-carboxylic acid

Base Information

• Chemical Name: 7-[4-(2-butoxyethoxy)phenyl]-2,3-dihydro-1H-1-benzazepine-4-carboxylic acid
• CAS No.: 497851-60-2
• Molecular Formula: C₂₃H₂₇NO₄
• Molecular Weight: 381.472

Synonyms:7-[4-(2-butoxyethoxy)phenyl]-2,3-dihydro-1H-1-benzazepine-4-carboxylic acid

Chemical Property of 7-[4-(2-butoxyethoxy)phenyl]-2,3-dihydro-1H-1-benzazepine-4-carboxylic acid

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Technology Process of 7-[4-(2-butoxyethoxy)phenyl]-2,3-dihydro-1H-1-benzazepine-4-carboxylic acid

There total 1 articles about 7-[4-(2-butoxyethoxy)phenyl]-2,3-dihydro-1H-1-benzazepine-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

methyl 7-{4-[2-(butoxy)ethoxy]phenyl}-2,3-dihydro-1H-1-benzazepine-4-carboxylate (313750-60-6) → 7-[4-(2-butoxyethoxy)phenyl]-2,3-dihydro-1H-1-benzazepine-4-carboxylic acid (497851-60-2)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; methanol; water; at 20 ℃; for 20h;

DOI:10.1248/cpb.52.818

Reference yield: 72.0%

trifluoroacetic anhydride (407-25-0) + 7-[4-(2-butoxyethoxy)phenyl]-2,3-dihydro-1H-1-benzazepine-4-carboxylic acid (497851-60-2) → 7-[4-(2-butoxyethoxy)phenyl]-1-(trifluoroacetyl)-2,3-dihydro-1H-1-benzazepine-4-carboxylic acid (497851-72-6)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 20 ℃; for 1h;

DOI:10.1248/cpb.52.818

Reference yield:

7-[4-(2-butoxyethoxy)phenyl]-2,3-dihydro-1H-1-benzazepine-4-carboxylic acid (497851-60-2) → C23H26ClNO3

Guidance literature:

With thionyl chloride; N,N-dimethyl-formamide; In tetrahydrofuran; at 0 - 20 ℃; for 1h;

upstream raw materials:

methyl 7-{4-[2-(butoxy)ethoxy]phenyl}-2,3-dihydro-1H-1-benzazepine-4-carboxylate

Downstream raw materials:

7-[4-(2-butoxyethoxy)phenyl]-1-(trifluoroacetyl)-2,3-dihydro-1H-1-benzazepine-4-carboxylic acid

7-[4-(2-butoxyethoxy)phenyl]-N-{4-[hydroxy(1-oxidopyridin-2-yl)methyl]-3-methoxyphenyl}-2,3-dihydro-1H-1-benzazepine-4-carboxamide

7-[4-(2-butoxyethoxy)phenyl]-N-{4-[hydroxy(4-methyl-1-oxidopyridin-2-yl)methyl]phenyl}-2,3-dihydro-1H-1-benzazepine-4-carboxamide

7-[4-(2-butoxyethoxy)phenyl]-N-{4-[hydroxy(5-methyl-1-oxidopyridin-2-yl)methyl]phenyl}-2,3-dihydro-1H-1-benzazepine-4-carboxamide

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