5-[4-(1-ethyl-1-{4-[5-(1-ethyl-1-hydroxypropyl)-3-methyl-thiophen-2-yl]-3-methyl-phenyl}-propyl)-2-methyl-phenoxy]-4(R)-hydroxy-pentanoic acid

Base Information

Chemical Name:5-[4-(1-ethyl-1-{4-[5-(1-ethyl-1-hydroxypropyl)-3-methyl-thiophen-2-yl]-3-methyl-phenyl}-propyl)-2-methyl-phenoxy]-4(R)-hydroxy-pentanoic acid
CAS No.:917022-83-4
Molecular Formula:C₃₄H₄₆O₅S
Molecular Weight:566.802
Hs Code.:

Synonyms:5-[4-(1-ethyl-1-{4-[5-(1-ethyl-1-hydroxypropyl)-3-methyl-thiophen-2-yl]-3-methyl-phenyl}-propyl)-2-methyl-phenoxy]-4(R)-hydroxy-pentanoic acid

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Chemical Property of 5-[4-(1-ethyl-1-{4-[5-(1-ethyl-1-hydroxypropyl)-3-methyl-thiophen-2-yl]-3-methyl-phenyl}-propyl)-2-methyl-phenoxy]-4(R)-hydroxy-pentanoic acid

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Technology Process of 5-[4-(1-ethyl-1-{4-[5-(1-ethyl-1-hydroxypropyl)-3-methyl-thiophen-2-yl]-3-methyl-phenyl}-propyl)-2-methyl-phenoxy]-4(R)-hydroxy-pentanoic acid

There total 6 articles about 5-[4-(1-ethyl-1-{4-[5-(1-ethyl-1-hydroxypropyl)-3-methyl-thiophen-2-yl]-3-methyl-phenyl}-propyl)-2-methyl-phenoxy]-4(R)-hydroxy-pentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 917024-78-3
5-(4-{1-[4-(t-butyl-dimethyl-silanyloxy)-3-methyl-phenyl]-1-ethyl-propyl}-2-methyl-phenyl)-4-methyl-thiophene-2-carboxylic acid methyl ester

: 925-90-6
ethylmagnesium bromide

: 58879-33-7
(R)-(-)-γ-<(tosyloxy)methyl>-γ-butyrolactone

: 917022-83-4
5-[4-(1-ethyl-1-{4-[5-(1-ethyl-1-hydroxypropyl)-3-methyl-thiophen-2-yl]-3-methyl-phenyl}-propyl)-2-methyl-phenoxy]-4(R)-hydroxy-pentanoic acid

Guidance literature:: 5-(4-{1-[4-(t-butyl-dimethyl-silanyloxy)-3-methyl-phenyl]-1-ethyl-propyl}-2-methyl-phenyl)-4-methyl-thiophene-2-carboxylic acid methyl ester; ethylmagnesium bromide; In tetrahydrofuran; at 0 ℃; for 3h;

With water; In tetrahydrofuran; water; ethyl acetate;

(R)-(-)-γ-<(tosyloxy)methyl>-γ-butyrolactone; With tetrabutyl ammonium fluoride; potassium carbonate; more than 3 stages;

Reference yield:

: 865235-89-8
trifluoromethanesulfonic acid 4-[1-ethyl-1-(4-hydroxy-3-methylphenyl)-propyl]-2-methylphenyl ester

: 917022-83-4
5-[4-(1-ethyl-1-{4-[5-(1-ethyl-1-hydroxypropyl)-3-methyl-thiophen-2-yl]-3-methyl-phenyl}-propyl)-2-methyl-phenoxy]-4(R)-hydroxy-pentanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 16 h / 80 °C

2: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; toluene / 17 h / 85 °C

3: 1H-imidazole / N,N-dimethyl-formamide / 0.2 h / 20 °C

4: tetrahydrofuran / 3 h / 0 °C

With 1H-imidazole; potassium acetate; sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;

Reference yield:

: 917024-63-6
4-{1-ethyl-1-[3-methyl-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-propyl}-2-methyl-phenol

: 917022-83-4
5-[4-(1-ethyl-1-{4-[5-(1-ethyl-1-hydroxypropyl)-3-methyl-thiophen-2-yl]-3-methyl-phenyl}-propyl)-2-methyl-phenoxy]-4(R)-hydroxy-pentanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; toluene / 17 h / 85 °C

2: 1H-imidazole / N,N-dimethyl-formamide / 0.2 h / 20 °C

3: tetrahydrofuran / 3 h / 0 °C

With 1H-imidazole; sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; water; N,N-dimethyl-formamide; toluene;