N-(1(S)-phenyl-3(R)-methylcyclohexyl)-5-chlorovaleramide

Base Information

• Chemical Name: N-(1(S)-phenyl-3(R)-methylcyclohexyl)-5-chlorovaleramide
• CAS No.: 114693-38-8
• Molecular Formula: C₁₈H₂₆ClNO
• Molecular Weight: 307.864
• Mol file: 114693-38-8.mol

Synonyms:N-(1(S)-phenyl-3(R)-methylcyclohexyl)-5-chlorovaleramide

Chemical Property of N-(1(S)-phenyl-3(R)-methylcyclohexyl)-5-chlorovaleramide

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of N-(1(S)-phenyl-3(R)-methylcyclohexyl)-5-chlorovaleramide

There total 1 articles about N-(1(S)-phenyl-3(R)-methylcyclohexyl)-5-chlorovaleramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

(1S,3R)-3-Methyl-1-phenyl-cyclohexylamine; compound with (E)-but-2-enedioic acid (114817-16-2) → N-(1(S)-phenyl-3(R)-methylcyclohexyl)-5-chlorovaleramide (114693-38-8)

Guidance literature:

With sodium carbonate; In chloroform; for 0.333333h;

DOI:10.1021/jm00403a023

Reference yield: 92.0%

N-(1(S)-phenyl-3(R)-methylcyclohexyl)-5-chlorovaleramide (114693-38-8) → N-(1(S)-phenyl-3(R)-methylcyclohexyl)-δ-valerolactam (114693-39-9)

Guidance literature:

With sodium hydride; In diethyl ether; for 3h; Heating;

DOI:10.1021/jm00403a023

Reference yield:

N-(1(S)-phenyl-3(R)-methylcyclohexyl)-5-chlorovaleramide (114693-38-8) → 1-Phenyl-3-methyl-cyclohexylpiperidin (114760-75-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 92 percent / sodium hydride / diethyl ether / 3 h / Heating

2: 84 percent / lithium aluminum hydride / tetrahydrofuran / 1 h / Heating

With lithium aluminium tetrahydride; sodium hydride; In tetrahydrofuran; diethyl ether;

DOI:10.1021/jm00403a023

upstream raw materials:

(1S,3R)-3-Methyl-1-phenyl-cyclohexylamine; compound with (E)-but-2-enedioic acid

Downstream raw materials:

N-(1(S)-phenyl-3(R)-methylcyclohexyl)-δ-valerolactam

1-Phenyl-3-methyl-cyclohexylpiperidin