4-{3-methoxy-5-oxo-2-[1-(toluene-4-sulfonyl)-1H-indol-3-yl]-9-triisopropylsilanyloxy-8,9-dihydro-5H-cycloheptapyrazin-6-yl}-2,2-dimethyl-5-vinyl-oxazole-3-carboxylic acid tert-butyl ester

Base Information

Chemical Name:4-{3-methoxy-5-oxo-2-[1-(toluene-4-sulfonyl)-1H-indol-3-yl]-9-triisopropylsilanyloxy-8,9-dihydro-5H-cycloheptapyrazin-6-yl}-2,2-dimethyl-5-vinyl-oxazole-3-carboxylic acid tert-butyl ester
CAS No.:911677-81-1
Molecular Formula:C₄₆H₅₈N₄O₈SSi
Molecular Weight:855.14
Hs Code.:

4-{3-methoxy-5-oxo-2-[1-(toluene-4-sulfonyl)-1<i>H</i>-indol-3-yl]-9-triisopropylsilanyloxy-8,9-dihydro-5<i>H</i>-cycloheptapyrazin-6-yl}-2,2-dimethyl-5-vinyl-oxazole-3-carboxylic acid <i>tert</i>-butyl ester

Synonyms:4-{3-methoxy-5-oxo-2-[1-(toluene-4-sulfonyl)-1H-indol-3-yl]-9-triisopropylsilanyloxy-8,9-dihydro-5H-cycloheptapyrazin-6-yl}-2,2-dimethyl-5-vinyl-oxazole-3-carboxylic acid tert-butyl ester

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Chemical Property of 4-{3-methoxy-5-oxo-2-[1-(toluene-4-sulfonyl)-1H-indol-3-yl]-9-triisopropylsilanyloxy-8,9-dihydro-5H-cycloheptapyrazin-6-yl}-2,2-dimethyl-5-vinyl-oxazole-3-carboxylic acid tert-butyl ester

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Technology Process of 4-{3-methoxy-5-oxo-2-[1-(toluene-4-sulfonyl)-1H-indol-3-yl]-9-triisopropylsilanyloxy-8,9-dihydro-5H-cycloheptapyrazin-6-yl}-2,2-dimethyl-5-vinyl-oxazole-3-carboxylic acid tert-butyl ester

There total 10 articles about 4-{3-methoxy-5-oxo-2-[1-(toluene-4-sulfonyl)-1H-indol-3-yl]-9-triisopropylsilanyloxy-8,9-dihydro-5H-cycloheptapyrazin-6-yl}-2,2-dimethyl-5-vinyl-oxazole-3-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 2,2-dimethyl-4-trimethylstannanyl-5-vinyl-oxazole-3-carboxylic acid tert-butyl ester

: 911677-77-5
6-iodo-3-methoxy-2-[1-(toluene-4-sulfonyl)-1H-indol-3-yl]-9-triisopropylsilanyloxy-8,9-dihydro-cycloheptapyrazin-5-one

: 911677-81-1
4-{3-methoxy-5-oxo-2-[1-(toluene-4-sulfonyl)-1H-indol-3-yl]-9-triisopropylsilanyloxy-8,9-dihydro-5H-cycloheptapyrazin-6-yl}-2,2-dimethyl-5-vinyl-oxazole-3-carboxylic acid tert-butyl ester

Guidance literature:: With copper(l) chloride; lithium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In dimethyl sulfoxide; at 20 ℃; for 0.5h;
DOI:10.1021/ol0617547

Reference yield:

: 911677-86-6
1-(3-bromo-6-iodo-5-methoxy-pyrazin-2-yl)-hex-5-en-1-ol

: 911677-81-1
4-{3-methoxy-5-oxo-2-[1-(toluene-4-sulfonyl)-1H-indol-3-yl]-9-triisopropylsilanyloxy-8,9-dihydro-5H-cycloheptapyrazin-6-yl}-2,2-dimethyl-5-vinyl-oxazole-3-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 86 percent / imidazole / dimethylformamide / 16 h / 40 °C

2: 85 percent / LiCl; CuCl / Pd(PPh₃)4 / dimethylsulfoxide / 0.5 h / 20 °C

3: 82 percent / NaOAc / Pd(PPh₃)4 / dimethylformamide / 2 h / 150 °C

4: 80 percent / N-methylmorpholine-N-oxide; OsO₄; NaIO₄ / tetrahydrofuran; H₂O / 20 h / 20 °C

5: Pd(OAc)2 / acetonitrile / 20 h / 20 °C

6: 917 mg / LiHMDS / tetrahydrofuran / -78 - -50 °C

7: 86 percent / iodine / CCl₄; pyridine / 24 h / 20 °C

8: 71 percent / LiCl; CuCl / Pd(PPh₃)4 / dimethylsulfoxide / 0.5 h / 20 °C

With 1H-imidazole; sodium periodate; osmium(VIII) oxide; iodine; sodium acetate; 4-methylmorpholine N-oxide; copper(l) chloride; lithium chloride; lithium hexamethyldisilazane; palladium diacetate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; pyridine; tetrachloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile; 2: Stille coupling reaction / 3: Heck reaction / 4: Saegusa oxidation / 5: Saegusa oxidation / 8: Stille coupling reaction;
DOI:10.1021/ol0617547

Reference yield:

: 911677-73-1
2-bromo-5-iodo-6-methoxy-3-(1-triisopropylsilanyloxy-hex-5-enyl)-pyrazine

: 911677-81-1
4-{3-methoxy-5-oxo-2-[1-(toluene-4-sulfonyl)-1H-indol-3-yl]-9-triisopropylsilanyloxy-8,9-dihydro-5H-cycloheptapyrazin-6-yl}-2,2-dimethyl-5-vinyl-oxazole-3-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 85 percent / LiCl; CuCl / Pd(PPh₃)4 / dimethylsulfoxide / 0.5 h / 20 °C

2: 82 percent / NaOAc / Pd(PPh₃)4 / dimethylformamide / 2 h / 150 °C

3: 80 percent / N-methylmorpholine-N-oxide; OsO₄; NaIO₄ / tetrahydrofuran; H₂O / 20 h / 20 °C

4: Pd(OAc)2 / acetonitrile / 20 h / 20 °C

5: 917 mg / LiHMDS / tetrahydrofuran / -78 - -50 °C

6: 86 percent / iodine / CCl₄; pyridine / 24 h / 20 °C

7: 71 percent / LiCl; CuCl / Pd(PPh₃)4 / dimethylsulfoxide / 0.5 h / 20 °C

With sodium periodate; osmium(VIII) oxide; iodine; sodium acetate; 4-methylmorpholine N-oxide; copper(l) chloride; lithium chloride; lithium hexamethyldisilazane; palladium diacetate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; pyridine; tetrachloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile; 1: Stille coupling reaction / 2: Heck reaction / 3: Saegusa oxidation / 4: Saegusa oxidation / 7: Stille coupling reaction;
DOI:10.1021/ol0617547