5-iodo-5'-O-(dimethoxytrityl)-4-N-benzoyl-2'-deoxycytidine

Base Information

• Chemical Name: 5-iodo-5'-O-(dimethoxytrityl)-4-N-benzoyl-2'-deoxycytidine
• CAS No.: 232616-75-0
• Molecular Formula: C₃₇H₃₄IN₃O₇
• Molecular Weight: 759.597
• Mol file: 232616-75-0.mol

Synonyms:5-iodo-5'-O-(dimethoxytrityl)-4-N-benzoyl-2'-deoxycytidine

Chemical Property of 5-iodo-5'-O-(dimethoxytrityl)-4-N-benzoyl-2'-deoxycytidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-iodo-5'-O-(dimethoxytrityl)-4-N-benzoyl-2'-deoxycytidine

There total 1 articles about 5-iodo-5'-O-(dimethoxytrityl)-4-N-benzoyl-2'-deoxycytidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

4,4'-dimethoxytrityl chloride (40615-36-9) + C16H16IN3O5 (158042-39-8) → 5-iodo-5'-O-(dimethoxytrityl)-4-N-benzoyl-2'-deoxycytidine (232616-75-0)

Guidance literature:

With pyridine; triethylamine; at 20 ℃; for 18h; Inert atmosphere;

DOI:10.1021/acs.joc.6b01584

Reference yield: 59.0%

5-iodo-5'-O-(dimethoxytrityl)-4-N-benzoyl-2'-deoxycytidine (232616-75-0) + C16H15N3 → C36H33N3O7

Guidance literature:

5-iodo-5'-O-(dimethoxytrityl)-4-N-benzoyl-2'-deoxycytidine; C₁₆H₁₅N₃; With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; In N,N-dimethyl-formamide; at 50 ℃; for 4h; Inert atmosphere; Darkness;

With triethylamine; In ethanol; N,N-dimethyl-formamide; at 70 ℃; for 18h; Inert atmosphere; Darkness;

DOI:10.1021/acs.joc.6b01584

Reference yield: 57.0%

N-(3-(4-ethynyl-1H-1,2,3-triazol-1-yl)propyl)-2,2,2-trifluoroacetamide (1360536-89-5) + 5-iodo-5'-O-(dimethoxytrityl)-4-N-benzoyl-2'-deoxycytidine (232616-75-0) → 3-[2-deoxy-5-O-(4,4'-dimethoxytrityl)-beta-D-erythropentofuranosyl]-6-([1H-(1',2',3'-triazol-4'-yl)propyl]-2-trifluoroacetamido)-2-oxo-3,7-dihydro-2H-pyrrolo[2,3-d]pyrimidine

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; In N,N-dimethyl-formamide; at 50 ℃; for 24h;

DOI:10.1039/c2ob06606h

upstream raw materials:

4,4'-dimethoxytrityl chloride

C₁₆H₁₆IN₃O₅