(1R,2R,3S,5R,6R,8S)-2,3-diacetyloxy-8-hydroxy-1-(4,4'-dimethoxytrityloxymethyl)-6-(uracil-1-yl)-7-oxabicyclo-[3.2.1]octane

Base Information

• Chemical Name: (1R,2R,3S,5R,6R,8S)-2,3-diacetyloxy-8-hydroxy-1-(4,4'-dimethoxytrityloxymethyl)-6-(uracil-1-yl)-7-oxabicyclo-[3.2.1]octane
• CAS No.: 1186001-90-0
• Molecular Formula: C₃₇H₃₈N₂O₁₁
• Molecular Weight: 686.716

Synonyms:(1R,2R,3S,5R,6R,8S)-2,3-diacetyloxy-8-hydroxy-1-(4,4'-dimethoxytrityloxymethyl)-6-(uracil-1-yl)-7-oxabicyclo-[3.2.1]octane

Chemical Property of (1R,2R,3S,5R,6R,8S)-2,3-diacetyloxy-8-hydroxy-1-(4,4'-dimethoxytrityloxymethyl)-6-(uracil-1-yl)-7-oxabicyclo-[3.2.1]octane

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Technology Process of (1R,2R,3S,5R,6R,8S)-2,3-diacetyloxy-8-hydroxy-1-(4,4'-dimethoxytrityloxymethyl)-6-(uracil-1-yl)-7-oxabicyclo-[3.2.1]octane

There total 1 articles about (1R,2R,3S,5R,6R,8S)-2,3-diacetyloxy-8-hydroxy-1-(4,4'-dimethoxytrityloxymethyl)-6-(uracil-1-yl)-7-oxabicyclo-[3.2.1]octane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C16H20N2O9 (1186001-89-7) + 4,4'-dimethoxytrityl chloride (40615-36-9) → (1R,2R,3S,5R,6R,8S)-2,3-diacetyloxy-8-hydroxy-1-(4,4'-dimethoxytrityloxymethyl)-6-(uracil-1-yl)-7-oxabicyclo-[3.2.1]octane (1186001-90-0)

Guidance literature:

With pyridine; In acetonitrile; at 20 ℃; for 27h; Inert atmosphere;

DOI:10.1021/jo9013657

Reference yield: 100.0%

(1R,2R,3S,5R,6R,8S)-2,3-diacetyloxy-8-hydroxy-1-(4,4'-dimethoxytrityloxymethyl)-6-(uracil-1-yl)-7-oxabicyclo-[3.2.1]octane (1186001-90-0) + 2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine (124482-92-4,89992-70-1) → (1S,2S,3S,5R,6R,8S)-2,3-diacetyloxy-8-cyanoethoxy(diisopropylamino)phosphinoxy-1-(4,4'-dimethoxytrityloxymethyl)-6-(uracil-1-yl)-7-oxabicyclo[3.2.1]octane (1186001-91-1)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In 1,2-dichloro-ethane; at 20 ℃; Inert atmosphere;

DOI:10.1021/jo9013657

upstream raw materials:

C₁₆H₂₀N₂O₉

4,4'-dimethoxytrityl chloride

Downstream raw materials:

(1S,2S,3S,5R,6R,8S)-2,3-diacetyloxy-8-cyanoethoxy(diisopropylamino)phosphinoxy-1-(4,4'-dimethoxytrityloxymethyl)-6-(uracil-1-yl)-7-oxabicyclo[3.2.1]octane

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