DL-2-amino-4-[(RSp)-(3-carboxymethylphenoxy) (methoxy)phosphoryl]butanoic acid

Base Information

• Chemical Name: DL-2-amino-4-[(RSp)-(3-carboxymethylphenoxy) (methoxy)phosphoryl]butanoic acid
• CAS No.: 926281-37-0
• Molecular Formula: C₁₃H₁₈NO₇P
• Molecular Weight: 331.262
• Mol file: 926281-37-0.mol

Synonyms:DL-2-amino-4-[(RSp)-(3-carboxymethylphenoxy) (methoxy)phosphoryl]butanoic acid

Chemical Property of DL-2-amino-4-[(RSp)-(3-carboxymethylphenoxy) (methoxy)phosphoryl]butanoic acid

Chemical Property:

• Boiling Point: 557.7±50.0 °C(Predicted)
• Density: 1.403±0.06 g/cm3(Predicted)

Purity/Quality:

97% ^*data from raw suppliers

GGsTop ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: Nahlsgen is a highly selective, and irreversible γ-?glutamyl transpeptidase (GGT) inhibitor with no inhibitory activity on glutamine amidotransferases.

Technology Process of DL-2-amino-4-[(RSp)-(3-carboxymethylphenoxy) (methoxy)phosphoryl]butanoic acid

There total 2 articles about DL-2-amino-4-[(RSp)-(3-carboxymethylphenoxy) (methoxy)phosphoryl]butanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

benzyl 4-{[3-(benzyloxycarbonylmethyl)phenoxy](methoxy)phosphoryl}-2-[(diphenylmethylene)amino]butanoate → DL-2-amino-4-[(RSp)-(3-carboxymethylphenoxy) (methoxy)phosphoryl]butanoic acid (926281-37-0)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; for 4h;

DOI:10.1016/j.tetlet.2017.08.019

Reference yield: 51.0%

benzyl 2-(N-benzyloxycarbonylamino)-4-{[3-(benzyloxycarbonylmethyl)phenyl] (methyl)phosphono}butanoate (926281-36-9) → DL-2-amino-4-[(RSp)-(3-carboxymethylphenoxy) (methoxy)phosphoryl]butanoic acid (926281-37-0)

Guidance literature:

With hydrogen; 5%-palladium/activated carbon; In methanol; water; at 20 ℃; for 2.5h;

Reference yield:

DL-2-amino-4-[(RSp)-(3-carboxymethylphenoxy) (methoxy)phosphoryl]butanoic acid (926281-37-0) → C13H17NO7P(1-)*Na(1+)

Guidance literature:

With sodium hydroxide; In methanol; at 0 ℃; for 0.0833333h; Solvent; Temperature;

upstream raw materials:

benzyl 2-(N-benzyloxycarbonylamino)-4-{[3-(benzyloxycarbonylmethyl)phenyl] (methyl)phosphono}butanoate