2-(acetoxymethyl)-1,1'-bis(diphenylphosphino)ferrocene

Base Information

• Chemical Name: 2-(acetoxymethyl)-1,1'-bis(diphenylphosphino)ferrocene
• CAS No.: 407626-15-7
• Molecular Formula: C₃₇H₃₂FeO₂P₂
• Molecular Weight: 626.454
• Mol file: 407626-15-7.mol

Synonyms:2-(acetoxymethyl)-1,1'-bis(diphenylphosphino)ferrocene

Chemical Property of 2-(acetoxymethyl)-1,1'-bis(diphenylphosphino)ferrocene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(acetoxymethyl)-1,1'-bis(diphenylphosphino)ferrocene

There total 1 articles about 2-(acetoxymethyl)-1,1'-bis(diphenylphosphino)ferrocene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

rac-2-(N,N-dimethylaminomethyl)-1,1'-bis(diphenylphosphanyl)ferrocene (74286-14-9,409095-06-3) + acetic anhydride (108-24-7) → 2-(acetoxymethyl)-1,1'-bis(diphenylphosphino)ferrocene (407626-15-7)

Guidance literature:

In acetic anhydride; under N2, standard Schlenk techniques; soln. of Fe complex in acetic anhydride heated at 100°C for 2 h; vol. reduced under low pressure; chromy. (silica, hexane/ethyl acetate (3/1));

DOI:10.1021/om010656g

Reference yield: 99.0%

2-(acetoxymethyl)-1,1'-bis(diphenylphosphino)ferrocene (407626-15-7) + water (7732-18-5) → 2-(hydroxymethyl)-1,1'-bis(diphenylphosphino)ferrocene (407626-16-8)

Guidance literature:

With n-BuLi; In diethyl ether; under N2, standard Schlenk techniques; n-BuLi (2.4 equiv.) added at 0°C to soln. of Fe complex in Et2O; stirred at room temp. for 2 h; hydrolyzed with water; aq. phase extd. with Et2O; combined org. phases washed with water; driedover Na2SO4; solvent removed under reduced pressure; chromy. (alumina, ethyl acetate);

DOI:10.1021/om010656g

upstream raw materials:

rac-2-(N,N-dimethylaminomethyl)-1,1'-bis(diphenylphosphanyl)ferrocene

acetic anhydride

Downstream raw materials:

2-(hydroxymethyl)-1,1'-bis(diphenylphosphino)ferrocene