methyl [2-bromo-4-(2-{(3S)-7-[5-chloro-2-(1H-tetrazol-1-yl)phenyl]-5-oxo1,2,3,5-tetrahydro-3-indolizinyl}-1H-imidazol-5-yl)-5-methoxyphenyl]carbamate

Base Information

Chemical Name:methyl [2-bromo-4-(2-{(3S)-7-[5-chloro-2-(1H-tetrazol-1-yl)phenyl]-5-oxo1,2,3,5-tetrahydro-3-indolizinyl}-1H-imidazol-5-yl)-5-methoxyphenyl]carbamate
CAS No.:1445863-87-5
Molecular Formula:C₂₇H₂₂BrClN₈O₄
Molecular Weight:637.88
Hs Code.:

Synonyms:methyl [2-bromo-4-(2-{(3S)-7-[5-chloro-2-(1H-tetrazol-1-yl)phenyl]-5-oxo1,2,3,5-tetrahydro-3-indolizinyl}-1H-imidazol-5-yl)-5-methoxyphenyl]carbamate

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Chemical Property of methyl [2-bromo-4-(2-{(3S)-7-[5-chloro-2-(1H-tetrazol-1-yl)phenyl]-5-oxo1,2,3,5-tetrahydro-3-indolizinyl}-1H-imidazol-5-yl)-5-methoxyphenyl]carbamate

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Technology Process of methyl [2-bromo-4-(2-{(3S)-7-[5-chloro-2-(1H-tetrazol-1-yl)phenyl]-5-oxo1,2,3,5-tetrahydro-3-indolizinyl}-1H-imidazol-5-yl)-5-methoxyphenyl]carbamate

There total 10 articles about methyl [2-bromo-4-(2-{(3S)-7-[5-chloro-2-(1H-tetrazol-1-yl)phenyl]-5-oxo1,2,3,5-tetrahydro-3-indolizinyl}-1H-imidazol-5-yl)-5-methoxyphenyl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1445865-60-0
(3S)-7-[5-chloro-2-(1H-1,2,3,4-tetrazol-1-yl)phenyl]-5-oxo-1,2,3,5-tetrahydroindolizine-3-carboxylic acid

: C₁₁H₁₃NO₄

: 1445863-86-4
methyl [4-(2-{(3S)-7-[5-chloro-2-(1H-tetrazol-1-yl)phenyl]-5-oxo-1,2,3,5-tetrahydro-3-indolizinyl}-1H-imidazol-5-yl)-3-methoxyphenyl]carbamate

: 1445863-87-5
methyl [2-bromo-4-(2-{(3S)-7-[5-chloro-2-(1H-tetrazol-1-yl)phenyl]-5-oxo1,2,3,5-tetrahydro-3-indolizinyl}-1H-imidazol-5-yl)-5-methoxyphenyl]carbamate

Guidance literature:: C₁₁H₁₃NO₄; With pyridinium hydrobromide perbromide; hydrogen bromide; acetic acid; at 5 - 20 ℃; for 5h;

(3S)-7-[5-chloro-2-(1H-1,2,3,4-tetrazol-1-yl)phenyl]-5-oxo-1,2,3,5-tetrahydroindolizine-3-carboxylic acid; With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 50 ℃; for 16h; Further stages;

Reference yield:

: 1445865-54-2
3-ethyl 8-methyl (3S)-7-hydroxy-5-oxo-1,2,3,5-tetrahydroindolizine-3,8-dicarboxylate

: 1445863-86-4
methyl [4-(2-{(3S)-7-[5-chloro-2-(1H-tetrazol-1-yl)phenyl]-5-oxo-1,2,3,5-tetrahydro-3-indolizinyl}-1H-imidazol-5-yl)-3-methoxyphenyl]carbamate

: 1445863-87-5
methyl [2-bromo-4-(2-{(3S)-7-[5-chloro-2-(1H-tetrazol-1-yl)phenyl]-5-oxo1,2,3,5-tetrahydro-3-indolizinyl}-1H-imidazol-5-yl)-5-methoxyphenyl]carbamate

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium hydroxide / 20 °C

2.1: hydrogenchloride; water / 20 h / 140 °C

3.1: sulfuric acid / 4 h / 100 °C

4.1: triethylamine / N,N-dimethyl-formamide / 1 h / 20 °C

5.1: cesium fluoride; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 0.5 h / 105 °C / Inert atmosphere

6.1: sodium hydroxide; methanol / 4 h / 20 °C

7.1: acetic acid / 0.5 h

7.2: 20 °C

8.1: acetic acid; pyridinium hydrobromide perbromide; hydrogen bromide / 5 h / 5 - 20 °C

8.2: 16 h / 50 °C

With hydrogenchloride; methanol; tetrakis(triphenylphosphine) palladium⁽⁰⁾; pyridinium hydrobromide perbromide; sulfuric acid; water; hydrogen bromide; acetic acid; triethylamine; cesium fluoride; sodium hydroxide; In 1,4-dioxane; N,N-dimethyl-formamide;

Reference yield:

: 1445865-57-5
ethyl (3S)-7-hydroxy-5-oxo-1,2,3,5-tetrahydroindolizine-3-carboxylate

: 1445863-86-4
methyl [4-(2-{(3S)-7-[5-chloro-2-(1H-tetrazol-1-yl)phenyl]-5-oxo-1,2,3,5-tetrahydro-3-indolizinyl}-1H-imidazol-5-yl)-3-methoxyphenyl]carbamate

: 1445863-87-5
methyl [2-bromo-4-(2-{(3S)-7-[5-chloro-2-(1H-tetrazol-1-yl)phenyl]-5-oxo1,2,3,5-tetrahydro-3-indolizinyl}-1H-imidazol-5-yl)-5-methoxyphenyl]carbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / N,N-dimethyl-formamide / 1 h / 20 °C

2.1: cesium fluoride; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 0.5 h / 105 °C / Inert atmosphere

3.1: sodium hydroxide; methanol / 4 h / 20 °C

4.1: acetic acid / 0.5 h

4.2: 20 °C

5.1: acetic acid; pyridinium hydrobromide perbromide; hydrogen bromide / 5 h / 5 - 20 °C

5.2: 16 h / 50 °C

With methanol; tetrakis(triphenylphosphine) palladium⁽⁰⁾; pyridinium hydrobromide perbromide; hydrogen bromide; acetic acid; triethylamine; cesium fluoride; sodium hydroxide; In 1,4-dioxane; N,N-dimethyl-formamide;