N-(diethylphosphoryl)-L-isoleucyl-O-<<(N-benzylamino)carbonyl>methyl>-L-tyrosylglycine methyl ester

Base Information

Chemical Name:N-(diethylphosphoryl)-L-isoleucyl-O-<<(N-benzylamino)carbonyl>methyl>-L-tyrosylglycine methyl ester
CAS No.:122900-07-6
Molecular Formula:C₃₁H₄₅N₄O₉P
Molecular Weight:648.693
Hs Code.:

Synonyms:N-(diethylphosphoryl)-L-isoleucyl-O-<<(N-benzylamino)carbonyl>methyl>-L-tyrosylglycine methyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(diethylphosphoryl)-L-isoleucyl-O-<<(N-benzylamino)carbonyl>methyl>-L-tyrosylglycine methyl ester

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Technology Process of N-(diethylphosphoryl)-L-isoleucyl-O-<<(N-benzylamino)carbonyl>methyl>-L-tyrosylglycine methyl ester

There total 2 articles about N-(diethylphosphoryl)-L-isoleucyl-O-<<(N-benzylamino)carbonyl>methyl>-L-tyrosylglycine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 122899-90-5
N-(diethylphosphoryl)-L-isoleucine

: {(S)-2-Amino-3-[4-(benzylcarbamoyl-methoxy)-phenyl]-propionylamino}-acetic acid methyl ester

: 122900-07-6
N-(diethylphosphoryl)-L-isoleucyl-O-<<(N-benzylamino)carbonyl>methyl>-L-tyrosylglycine methyl ester

Guidance literature:: With dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; at 0 ℃; overnight;
DOI:10.1021/jm00163a044

Reference yield:

: 103310-88-9
L-isoleucine benzyl ester hydrochloride

: 122900-07-6
N-(diethylphosphoryl)-L-isoleucyl-O-<<(N-benzylamino)carbonyl>methyl>-L-tyrosylglycine methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 81 percent / 2,6-lutidine / CH₂Cl₂ / 2 h / -15 - 20 °C

2: 96 percent / H₂ / 10percent Pd/C / methanol / 760 Torr

3: 70 percent / DCC / dimethylformamide / 0 °C / overnight

With 2,6-dimethylpyridine; hydrogen; dicyclohexyl-carbodiimide; palladium on activated charcoal; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00163a044