(1R,6R)-6-Methyl-cyclohex-3-enecarboxylic acid 2-((R)-1-phenyl-ethylamino)-ethyl ester

Base Information

• Chemical Name: (1R,6R)-6-Methyl-cyclohex-3-enecarboxylic acid 2-((R)-1-phenyl-ethylamino)-ethyl ester
• CAS No.: 92284-53-2
• Molecular Formula: C₁₈H₂₅NO₂
• Molecular Weight: 287.402
• Mol file: 92284-53-2.mol

Synonyms:(1R,6R)-6-Methyl-cyclohex-3-enecarboxylic acid 2-((R)-1-phenyl-ethylamino)-ethyl ester

Chemical Property of (1R,6R)-6-Methyl-cyclohex-3-enecarboxylic acid 2-((R)-1-phenyl-ethylamino)-ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1R,6R)-6-Methyl-cyclohex-3-enecarboxylic acid 2-((R)-1-phenyl-ethylamino)-ethyl ester

There total 4 articles about (1R,6R)-6-Methyl-cyclohex-3-enecarboxylic acid 2-((R)-1-phenyl-ethylamino)-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(1R,6R)-6-Methyl-cyclohex-3-enecarboxylic acid (2-hydroxy-ethyl)-((R)-1-phenyl-ethyl)-amide (92284-49-6) → (1R,6R)-6-Methyl-cyclohex-3-enecarboxylic acid 2-((R)-1-phenyl-ethylamino)-ethyl ester (92284-53-2)

Guidance literature:

With hydrogenchloride; In tetrahydrofuran; for 6h; Heating;

DOI:10.1021/jo00198a012

Reference yield:

(R)-1-phenyl-ethyl-amine (3886-69-9) → (1R,6R)-6-Methyl-cyclohex-3-enecarboxylic acid 2-((R)-1-phenyl-ethylamino)-ethyl ester (92284-53-2)

Guidance literature:

Multi-step reaction with 3 steps

2: 1) LDA 2) HMPT / 1) THF, 0 deg C 2) 25 deg C, 16h

3: HCl / tetrahydrofuran / 6 h / Heating

With hydrogenchloride; N,N,N,N,N,N-hexamethylphosphoric triamide; lithium diisopropyl amide; In tetrahydrofuran;

DOI:10.1021/jo00198a012

Reference yield:

(1S,6S)-6-Methyl-cyclohex-3-enecarbonyl chloride (92284-36-1) → (1R,6R)-6-Methyl-cyclohex-3-enecarboxylic acid 2-((R)-1-phenyl-ethylamino)-ethyl ester (92284-53-2)

Guidance literature:

Multi-step reaction with 3 steps

2: 1) LDA 2) HMPT / 1) THF, 0 deg C 2) 25 deg C, 16h

3: HCl / tetrahydrofuran / 6 h / Heating

With hydrogenchloride; N,N,N,N,N,N-hexamethylphosphoric triamide; lithium diisopropyl amide; In tetrahydrofuran;

DOI:10.1021/jo00198a012

upstream raw materials:

(1R,6R)-6-Methyl-cyclohex-3-enecarboxylic acid (2-hydroxy-ethyl)-((R)-1-phenyl-ethyl)-amide

(R)-1-phenyl-ethyl-amine

(1S,6S)-6-Methyl-cyclohex-3-enecarbonyl chloride

(1R,6R)-6-Methyl-cyclohex-3-enecarboxylic acid ((R)-1-phenyl-ethyl)-amide

Downstream raw materials:

1R,6R-(+)-6-Methyl-3-cyclohexenyl-methanol

5t-Chlor-2t-methyl-cyclohexan-1r-carbonsaeure-tert-butylester

4c-Chlor-2t-methyl-cyclohexan-1r-carbonsaeure-tert-butylester

(-)-(1R,6R)-6-methyl-3-cyclohexenecarboxylic acid