7-amino-3-<2-<4-(2-bromo-4-fluorobenzoyl)-1-piperidinyl>ethyl>-2,4-(1H,3H)-quinazolinedione

Base Information

• Chemical Name: 7-amino-3-<2-<4-(2-bromo-4-fluorobenzoyl)-1-piperidinyl>ethyl>-2,4-(1H,3H)-quinazolinedione
• CAS No.: 102745-98-2
• Molecular Formula: C₂₂H₂₂BrFN₄O₃
• Molecular Weight: 489.344
• Mol file: 102745-98-2.mol

Synonyms:7-amino-3-<2-<4-(2-bromo-4-fluorobenzoyl)-1-piperidinyl>ethyl>-2,4-(1H,3H)-quinazolinedione

Chemical Property of 7-amino-3-<2-<4-(2-bromo-4-fluorobenzoyl)-1-piperidinyl>ethyl>-2,4-(1H,3H)-quinazolinedione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 7-amino-3-<2-<4-(2-bromo-4-fluorobenzoyl)-1-piperidinyl>ethyl>-2,4-(1H,3H)-quinazolinedione

There total 4 articles about 7-amino-3-<2-<4-(2-bromo-4-fluorobenzoyl)-1-piperidinyl>ethyl>-2,4-(1H,3H)-quinazolinedione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 15.0%

7-amino-3-(2-chloroethyl)-2,4(1H,3H)-quinazolinedione (101389-50-8) + 4-(2-bromo-4-fluorobenzoyl)piperidine hydrochloride (102779-93-1) → 7-amino-3-<2-<4-(2-bromo-4-fluorobenzoyl)-1-piperidinyl>ethyl>-2,4-(1H,3H)-quinazolinedione (102745-98-2)

Guidance literature:

With sodium carbonate; potassium iodide; In various solvent(s); for 20h; Heating;

DOI:10.1021/jm00159a017

Reference yield:

3-fluorobromobenzene (1073-06-9) → 7-amino-3-<2-<4-(2-bromo-4-fluorobenzoyl)-1-piperidinyl>ethyl>-2,4-(1H,3H)-quinazolinedione (102745-98-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 22 percent / AlCl₃ / 2 h / 80 °C

2: 78 percent / concd. HCl / 3 h / Heating

3: 15 percent / Na₂CO₃, KI / various solvent(s) / 20 h / Heating

With hydrogenchloride; aluminium trichloride; sodium carbonate; potassium iodide; In various solvent(s);

DOI:10.1021/jm00159a017

Reference yield:

1-acetylpiperidine-4-carbonyl chloride (59084-16-1) → 7-amino-3-<2-<4-(2-bromo-4-fluorobenzoyl)-1-piperidinyl>ethyl>-2,4-(1H,3H)-quinazolinedione (102745-98-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 22 percent / AlCl₃ / 2 h / 80 °C

2: 78 percent / concd. HCl / 3 h / Heating

3: 15 percent / Na₂CO₃, KI / various solvent(s) / 20 h / Heating

With hydrogenchloride; aluminium trichloride; sodium carbonate; potassium iodide; In various solvent(s);

DOI:10.1021/jm00159a017

upstream raw materials:

7-amino-3-(2-chloroethyl)-2,4(1H,3H)-quinazolinedione

4-(2-bromo-4-fluorobenzoyl)piperidine hydrochloride

3-fluorobromobenzene

1-acetylpiperidine-4-carbonyl chloride

Downstream raw materials:

7-amino-3-<2-<4-(2-tritio-4-fluorobenzoyl)-1-piperidinyl>ethyl>-2,4-(1H,3H)-quinazolinedione