C₁₉H₁₇F₃N₂OSe

Base Information

• Chemical Name: C₁₉H₁₇F₃N₂OSe
• CAS No.: 1332497-90-1
• Molecular Formula: C₁₉H₁₇F₃N₂OSe
• Molecular Weight: 425.312
• Mol file: 1332497-90-1.mol

Synonyms:C₁₉H₁₇F₃N₂OSe

Chemical Property of C₁₉H₁₇F₃N₂OSe

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₉H₁₇F₃N₂OSe

There total 6 articles about C₁₉H₁₇F₃N₂OSe which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

C12H11F3N2Se (1332498-02-8) + 4-iodo-2-methyl-phenol (60577-30-2) → C19H17F3N2OSe (1332497-90-1)

Guidance literature:

With copper(l) iodide; 2-(2-methyl-1-oxopropane)cyclohexanone; caesium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 8h; Inert atmosphere;

Reference yield:

4-(trifluoromethyl)benzoselenoamide (1332497-98-9) → C19H17F3N2OSe (1332497-90-1)

Guidance literature:

Multi-step reaction with 4 steps

1.1: tetrahydrofuran / 12.83 h / 20 - 80 °C / Reflux

1.2: 0.33 h / 20 °C

2.1: diisobutylaluminium hydride / dichloromethane; hexane / 1.5 h / -78 - -10 °C / Inert atmosphere

3.1: sodium azide; triphenylphosphine / N,N-dimethyl-formamide; tetrachloromethane / 90 °C

4.1: caesium carbonate; copper(l) iodide; 2-(2-methyl-1-oxopropane)cyclohexanone / N,N-dimethyl-formamide / 8 h / 20 °C / Inert atmosphere

With copper(l) iodide; sodium azide; 2-(2-methyl-1-oxopropane)cyclohexanone; diisobutylaluminium hydride; caesium carbonate; triphenylphosphine; In tetrahydrofuran; tetrachloromethane; hexane; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

C14H12F3NO2Se (1332497-99-0) → C19H17F3N2OSe (1332497-90-1)

Guidance literature:

Multi-step reaction with 3 steps

1: diisobutylaluminium hydride / dichloromethane; hexane / 1.5 h / -78 - -10 °C / Inert atmosphere

2: sodium azide; triphenylphosphine / N,N-dimethyl-formamide; tetrachloromethane / 90 °C

3: caesium carbonate; copper(l) iodide; 2-(2-methyl-1-oxopropane)cyclohexanone / N,N-dimethyl-formamide / 8 h / 20 °C / Inert atmosphere

With copper(l) iodide; sodium azide; 2-(2-methyl-1-oxopropane)cyclohexanone; diisobutylaluminium hydride; caesium carbonate; triphenylphosphine; In tetrachloromethane; hexane; dichloromethane; N,N-dimethyl-formamide;

upstream raw materials:

4-CF₃C₆H₄CN

C₁₂H₁₁F₃N₂Se

4-iodo-2-methyl-phenol

4-(trifluoromethyl)benzoselenoamide