(2S)-N-(2-bromophenylmethyl)-pyroglutamic acid

Base Information

Chemical Name:(2S)-N-(2-bromophenylmethyl)-pyroglutamic acid
CAS No.:1615250-18-4
Molecular Formula:C₁₂H₁₂BrNO₃
Molecular Weight:298.136
Hs Code.:

Synonyms:(2S)-N-(2-bromophenylmethyl)-pyroglutamic acid

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Chemical Property of (2S)-N-(2-bromophenylmethyl)-pyroglutamic acid

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Technology Process of (2S)-N-(2-bromophenylmethyl)-pyroglutamic acid

There total 2 articles about (2S)-N-(2-bromophenylmethyl)-pyroglutamic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₃H₁₄BrNO₃

: 1615250-18-4
(2S)-N-(2-bromophenylmethyl)-pyroglutamic acid

Guidance literature:: With water; sodium carbonate; In methanol; at 0 - 20 ℃; for 5h;
DOI:10.1016/j.ejmech.2014.05.017

Reference yield:

: 3433-80-5
1-Bromo-2-bromomethyl-benzene

: 1615250-18-4
(2S)-N-(2-bromophenylmethyl)-pyroglutamic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -20 °C / Inert atmosphere

1.2: 4 h / 0 - 20 °C / Inert atmosphere

2.1: sodium carbonate; water / methanol / 5 h / 0 - 20 °C

With water; sodium carbonate; lithium hexamethyldisilazane; In tetrahydrofuran; methanol;
DOI:10.1016/j.ejmech.2014.05.017

Reference yield: 89.0%

: 1615250-18-4
(2S)-N-(2-bromophenylmethyl)-pyroglutamic acid

: 227940-72-9
tert-Butyl 3,7-diazabicyclo[3.3.1]nonane-3-carboxylate

: 7-[1-(2-bromo-benzyl)-5-oxo-pyrrolidine-2-carbonyl]-3,7-diaza-bicyclo[3.3.1]nonane-3-carboxylic acid tert-butyl ester

Guidance literature:: (2S)-N-(2-bromophenylmethyl)-pyroglutamic acid; With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In dichloromethane; at 0 ℃; for 0.25h; Inert atmosphere;

tert-Butyl 3,7-diazabicyclo[3.3.1]nonane-3-carboxylate; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1016/j.ejmech.2016.01.019